Sedlmayr Peter, Kroneis Thomas
Center for Molecular Medicine; Institute of Cell Biology, Histology and Embryology; Medical University of Graz; Graz, Austria.
Chimerism. 2011 Jul;2(3):63-4. doi: 10.4161/chim.2.3.17741. Epub 2011 Jul 1.
Microchimerism has been studied in the context of a variety of diseases which include autoimmune diseases (such as systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroid diseases), cancer (e.g., of the cervix, thyroid gland, lung, breast), tissue repair, transplantation and transfusion. It may become relevant in the context of cell-based non-invasive prenatal diagnosis. But how to safely identify individual microchimeric cells? This is a nontrivial question, for which a solution has recently been suggested.
微嵌合体已在多种疾病的背景下进行了研究,这些疾病包括自身免疫性疾病(如系统性硬化症、类风湿性关节炎、系统性红斑狼疮和自身免疫性甲状腺疾病)、癌症(如宫颈癌、甲状腺癌、肺癌、乳腺癌)、组织修复、移植和输血。在基于细胞的非侵入性产前诊断中,它可能具有相关性。但是如何安全地识别单个微嵌合细胞呢?这是一个重要问题,最近有人提出了一种解决方案。