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阿尔茨海默病患者的情绪工作记忆

Emotional working memory in Alzheimer's disease patients.

作者信息

Satler Corina, Tomaz Carlos

机构信息

Department of Physiological Sciences, Laboratory of Neurosciences and Behavior, Institute of Biology, University of Brasília, Brasília, Brazil.

出版信息

Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):124-38. doi: 10.1159/000329155. Epub 2011 Jun 17.

DOI:10.1159/000329155
PMID:22163239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3199878/
Abstract

BACKGROUND

Few studies have assessed whether emotional content affects processes supporting working memory in Alzheimer disease (AD) patients.

METHODS

We assessed 22 AD patients and 40 elderly controls (EC) with a delayed matching and non-matching to sample task (DMST/DNMST), and a spatial-delayed recognition span task (SRST; unique/varied) using emotional stimuli.

RESULTS

AD patients showed decreased performance on both tasks compared with EC. With regard to the valence of the stimuli, we did not observe significant performance differences between groups in the DMST/DNMST. However, both groups remembered a larger number of negative than positive or neutral pictures on unique SRST.

CONCLUSION

The results suggest that AD patients show a relative preservation of working memory for emotional information, particularly for negative stimuli.

摘要

背景

很少有研究评估情绪内容是否会影响阿尔茨海默病（AD）患者支持工作记忆的过程。

方法

我们使用情绪刺激，通过延迟匹配和不匹配样本任务（DMST/DNMST）以及空间延迟识别跨度任务（SRST；独特/多样）评估了22名AD患者和40名老年对照（EC）。

结果

与EC相比，AD患者在两项任务上的表现均下降。关于刺激的效价，我们在DMST/DNMST中未观察到组间存在显著的表现差异。然而，在独特的SRST中，两组记住的负面图片数量均多于正面或中性图片。

结论

结果表明，AD患者对情绪信息，特别是负面刺激的工作记忆表现出相对保留。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/c515ed0345ba/dee0001-0124-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/33761be53f74/dee0001-0124-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/a1e434f44fbc/dee0001-0124-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/a18f5fd05dc3/dee0001-0124-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/c515ed0345ba/dee0001-0124-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/33761be53f74/dee0001-0124-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/a1e434f44fbc/dee0001-0124-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/a18f5fd05dc3/dee0001-0124-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef1/3199878/c515ed0345ba/dee0001-0124-f04.jpg

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