Zarubina I V, Shabanov P D
Eksp Klin Farmakol. 2011;74(9):35-8.
Experiments on rats showed that traumatic toxicosis (crush syndrome) was accompanied by disorders of both excretion and detoxication functions of the liver and a decrease in the energy potential of the liver. Systemic administration of cytochrome C (10 mg/kg) immediately after trauma and decompression increased the level of endogenous cytochrome C, recovered the pool of adenine nucleotides, normalized bromsulfaleine excretion from the blood, and decreased the content of toxic metabolites in the blood. The obtained experimental data show that cytochrome C possesses high hepatoprotective properties with respect to the development of traumatic toxicosis.
对大鼠的实验表明，创伤性中毒（挤压综合征）伴有肝脏排泄和解毒功能紊乱以及肝脏能量潜力降低。创伤和减压后立即全身给予细胞色素C（10毫克/千克）可提高内源性细胞色素C水平，恢复腺嘌呤核苷酸池，使血液中溴磺酚酞排泄正常化，并降低血液中有毒代谢物的含量。所获得的实验数据表明，细胞色素C对创伤性中毒的发展具有高度的肝脏保护特性。
