Rakhmatullaev F Kh, Khakimov Z Z
Central Research Laboratory, Second State Medical Institute, ul Farobi 2, Tashkent, 700109 Uzbekistan.
Eksp Klin Farmakol. 2001 Jan-Feb;64(1):71-3.
The compression syndrome was reproduced in rats aged one month and the efficacy of phytin in correcting the activity infringement and restoring the content of basic components of the hepatocyte monooxygenase enzyme system was studied in the postcompression period. The compression led to pronounced inhibition of the activity of aniline hydroxylase and amidopyrine M-demethylase, reduced the content of liver microsomal protein and cytochromes P-450 and b5, and increased the level of medium- molecular-weight (MMW) peptides in the blood serum. A six-day treatment with phytin restored the normal level of the liver monooxygenase system components and MMW peptides. Phytin reduced the level of lactic acid (LA) and increased that of pyruvic acid (PA) in liver tissues, which led to a sharp drop in the LA/MA ratio indicative of a decrease in the extent of hypoxia.
在1月龄大鼠中再现了压迫综合征，并研究了植酸在压迫后时期纠正肝细胞单加氧酶系统活性损害和恢复其基本成分含量的功效。压迫导致苯胺羟化酶和氨基比林N-脱甲基酶活性受到明显抑制，肝微粒体蛋白以及细胞色素P-450和b5的含量降低，并且血清中中等分子量（MMW）肽水平升高。用植酸进行为期6天的治疗可恢复肝单加氧酶系统成分和MMW肽的正常水平。植酸降低了肝组织中乳酸（LA）的水平并提高了丙酮酸（PA）的水平，这导致LA/MA比值急剧下降，表明缺氧程度降低。
