Zhou Yong-Hua, Huang Hong-Bo, Tao Yong-Hui, Yu Hui-Xin, Xu Yong-Liang, Zhang Ying, Gao Qi
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Wuxi 214064, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011 Jun;23(3):307-10.
To explore the effect of latent asymptomatic Toxoplasma gondii infection on glucose metabolism in brain of mice.
Twenty mice were randomly divided into two groups: a Toxoplasma infected group and normal control group. The mice in the Toxoplasma infected group were inoculated with 0.3 ml of brain suspension in saline containing ten Toxoplasma gondii tissue cysts, avirulent Toxoplasma gondii Prugniaud (PRU, a Type II strain). The mice in the control group received 0.3 ml of saline orally. Six monthes after the infection, the glucose metabolism changes in the mouse brain were evaluated by MicroPET, then all the mice were sacrificed and the brain tissues were observed histopathologically.
Compared with the normal controls, the infected mice demonstrated profound and widespread brain pathology, and MicroPET indicated a significant glucose metabolism reduction in the brain of asymptomatic Toxoplasma gondii infected mice.
Chronic Toxoplasma gondii infection maybe results in the glucose metabolism reduction in the brain of mice.
探讨潜伏无症状弓形虫感染对小鼠脑葡萄糖代谢的影响。
将20只小鼠随机分为两组：弓形虫感染组和正常对照组。弓形虫感染组小鼠接种0.3 ml含10个弓形虫组织包囊的生理盐水脑悬液，无毒力的弓形虫Prugniaud株（PRU，II型毒株）。对照组小鼠口服0.3 ml生理盐水。感染6个月后，通过MicroPET评估小鼠脑葡萄糖代谢变化，然后处死所有小鼠，对脑组织进行组织病理学观察。
与正常对照组相比，感染小鼠表现出广泛而严重的脑病理学改变，MicroPET显示无症状弓形虫感染小鼠脑葡萄糖代谢显著降低。
慢性弓形虫感染可能导致小鼠脑葡萄糖代谢降低。
