Guerrero O M, Chinchilla M, Castro A, Abrahams E
Departamento de Parasitología, Universidad de Costa Rica, San José.
Rev Biol Trop. 1995 Apr-Dec;43(1-3):27-30.
Groups of 1, 5, 10, 15 and 30 day old rats (Sprague Dawley) and Wistar mice were infected per os with different inocula of Toxoplasma gondii oocysts from an avirulent strain. Infection pattern was followed by determination of survival time, tissue lesions, parasite presence and serology. Although all the animals survived the total experimental period (30 day), there were important differences between both rodents regarding to Toxoplasma natural resistance. Brain cysts, as well as tachyzoites in other organs were regularly present in mice but not in rats. On the other hand, most of the organs from mice presented characteristic T. gondii lesions, while in rats a normal tissues were observed, with the exception of an acute reaction found in the brain of a 15d old animal.
将1日龄、5日龄、10日龄、15日龄和30日龄的大鼠（斯普拉格-道利大鼠）以及Wistar小鼠分组，经口感染来自无毒株的不同接种量的刚地弓形虫卵囊。通过测定存活时间、组织病变、寄生虫存在情况和血清学来跟踪感染模式。尽管所有动物都存活至整个实验期（30天），但两种啮齿动物在对弓形虫的天然抵抗力方面存在重要差异。小鼠体内经常出现脑囊肿以及其他器官中的速殖子，而大鼠体内则未出现。另一方面，小鼠的大多数器官呈现出典型的弓形虫病变，而大鼠的组织观察正常，只有一只15日龄动物的大脑出现了急性反应。
