Department of Pediatrics, Gachon University of Medicine and Science, Incheon, Republic of Korea.
Free Radic Res. 2012 Mar;46(3):231-9. doi: 10.3109/10715762.2011.649749. Epub 2012 Jan 25.
Peroxiredoxins (Prdx), a family of antioxidant proteins, have important defensive roles in the degenerative brain diseases and neuronal cell death in adult subjects. However, little is known in the neonatal brain. Here, we studied the developmental expression of Prdxs and their response to dexamethasone in the perinatal rat brain. Prdx 1 expression increased during late gestations and peaked at postnatal-day 1, when its expression gradually decreased. Prdx 2 expression remained largely unchanged. Prdx 6 expression continually increased as growing. Using immunohistochemistry, each Prdx showed a strong expression in the cerebral cortex and hippocampus. Prdx 1 was strongly expressed in the corpus callosum. The dexamethasone injection increased the expression of Prdx 6. In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment.
过氧化物酶（Prdx）是抗氧化蛋白家族的一员，在退行性脑疾病和成年受试者的神经元细胞死亡中具有重要的防御作用。然而，在新生儿大脑中知之甚少。在这里，我们研究了 Prdxs 的发育表达及其对围产期大鼠脑内地塞米松的反应。Prdx1 的表达在晚期妊娠期间增加，并在出生后第 1 天达到高峰，随后其表达逐渐下降。Prdx2 的表达基本保持不变。Prdx6 的表达随着生长而持续增加。通过免疫组织化学染色，每个 Prdx 在大脑皮层和海马体中都有强烈的表达。Prdx1 在胼胝体中表达强烈。地塞米松注射增加了 Prdx6 的表达。总之，我们首次揭示 Prdx1、2 和 6 在围产期大鼠脑中大量存在，并在发育过程中表达不同。Prdx6 的表达受地塞米松处理的影响。
