Xue Min, Huang Xiaojie, Zhu Tong, Zhang Lijun, Yang Hao, Shen Yuxian, Feng Lijie
School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Institute of Biopharmaceuticals, Anhui Medical University, Hefei 230032, China.
Antioxidants (Basel). 2024 Apr 10;13(4):449. doi: 10.3390/antiox13040449.
Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase activity, and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for the maintenance of lipid peroxidation repair, cellular metabolism, inflammatory signaling, and antioxidant damage. Growing research has demonstrated that the altered activity of this enzyme is linked with various pathological processes including central nervous system (CNS) disorders. This review discusses the distinctive structure, enzyme activity, and function of Prdx6 in different CNS disorders, as well as emphasizing the significance of Prdx6 in neurological disorders.
过氧化物酶体增殖物激活受体6（Prdx6）是过氧化物酶体增殖物激活受体家族中独特的1-半胱氨酸成员，具有过氧化物酶活性、磷脂酶活性和溶血磷脂酰胆碱酰基转移酶（LPCAT）活性。已知Prdx6是维持脂质过氧化修复、细胞代谢、炎症信号传导和抗氧化损伤的重要酶。越来越多的研究表明，这种酶活性的改变与包括中枢神经系统（CNS）疾病在内的各种病理过程有关。本文综述了Prdx6在不同CNS疾病中的独特结构、酶活性和功能，并强调了Prdx6在神经系统疾病中的重要性。
