Beard L J, Ferrante A
Department of Paediatrics, University of Adelaide, South Australia.
Pediatr Infect Dis J. 1990 Aug;9(8 Suppl):S54-61.
Immunoglobulin replacement therapy appears to benefit some patients who have IgG subclass deficiencies. Because some patients with subnormal trough concentrations of IgG subclasses remain well, because other patients who have borderline/low normal concentrations of an IgG subclass are abnormally infection-prone and helped by immunoglobulin therapy and because infection proneness in individual patients does not always appear to parallel their IgG subclass concentrations, it is evident that IgG subclass concentrations, while a helpful guide, are not an absolute determinant of the need for immunoglobulin replacement therapy in infection-prone patients. Low IgG subclass concentrations may indicate impaired ability to produce certain "specific" antibodies and antibody replacement is likely to be the crucial factor in treatment rather than merely maintaining concentrations of IgG subclasses at particular levels.
免疫球蛋白替代疗法似乎对一些存在IgG亚类缺陷的患者有益。由于一些IgG亚类谷浓度低于正常水平的患者仍状况良好，由于其他IgG亚类浓度处于临界/略低于正常水平的患者异常容易感染且免疫球蛋白治疗对其有帮助，还由于个体患者的易感染性并不总是与其IgG亚类浓度平行，显然，IgG亚类浓度虽然是一个有用的指标，但并非易感染患者免疫球蛋白替代疗法需求的绝对决定因素。低IgG亚类浓度可能表明产生某些“特异性”抗体的能力受损，抗体替代可能是治疗的关键因素，而不仅仅是将IgG亚类浓度维持在特定水平。
