Björkander J, Bengtsson U, Oxelius V A, Hanson L A
Monogr Allergy. 1986;20:157-63.
Several patients with subnormal levels of IgG subclasses have repeated infections. Further controlled studies are required to better define the relation between the level of the various subclasses and the possible clinical consequences. It may be important to determine whether or not IgG subclass deficiency can lead to infections which cause lung damage as was suggested in a few patients with IgA deficiency combined with low IgG subclass levels. An open study of the effect of immunoglobulin prophylaxis in 38 patients with subnormal levels of one or two of the IgG subclasses 1, 2 or 3 during altogether 1,524 months of observation suggested that many of them improved. This must be further substantiated in carefully controlled studies. Immunoglobulin prophylaxis could be given in IgG subclass deficient patients with IgA deficiency and anti-IgA antibodies, provided a preparation poor in IgA was used and the patients' anti-IgA titres did not increase during the prophylaxis.
几名免疫球蛋白G（IgG）亚类水平低于正常的患者反复感染。需要进一步的对照研究，以更好地明确各种亚类水平与可能的临床后果之间的关系。确定IgG亚类缺陷是否会像一些伴有低IgG亚类水平的IgA缺陷患者那样导致引起肺损伤的感染可能很重要。一项针对38名IgG亚类1、2或3中一两种水平低于正常的患者进行的免疫球蛋白预防效果的开放性研究，在总共1524个月的观察期内表明，他们中的许多人病情有所改善。这必须在严格对照的研究中得到进一步证实。对于伴有IgA缺陷和抗IgA抗体的IgG亚类缺陷患者，可以给予免疫球蛋白预防，前提是使用IgA含量低的制剂，并且在预防期间患者的抗IgA滴度不升高。
