慢性戊型肝炎导致 HIV 相关隐源性肝硬化。

Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV.

机构信息

HIV & Sexual Health Department, Chelsea and Westminster Hospital, London, United Kingdom.

出版信息

J Infect. 2013 Jan;66(1):103-6. doi: 10.1016/j.jinf.2011.11.027. Epub 2011 Dec 6.

DOI:10.1016/j.jinf.2011.11.027

Abstract

Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.

摘要

慢性戊型肝炎病毒（HEV）感染在免疫功能低下的患者中已有报道。一名 45 岁的 HIV 感染者在开始接受抗逆转录病毒治疗之前，其持续性转氨升高的原因不明。肝弹性成像和肝活检显示为肝硬化。2010 年，他的 HEV IgM/IgG 抗体检测呈阳性。检测到血浆 HEV RNA。存档样本显示自 2000 年以来一直存在 HEV 病毒血症。开始了 24 周的聚乙二醇干扰素治疗，在治疗停止后的第 4 周到第 27 周，HEV RNA 检测不到。在 HIV 患者中，不明原因的转氨升高和隐匿性肝硬化应考虑慢性 HEV 感染。