Butt F M A, Chindia M L, Rana F
Department of Human Anatomy, University of Nairobi, Kenya.
J Laryngol Otol. 2012 Mar;126(3):276-8. doi: 10.1017/S0022215111002647. Epub 2011 Dec 14.
Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives.
To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus.
Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus.
Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18-43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification).
Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.
随着高效抗逆转录病毒疗法的出现，大多数人类免疫缺陷病毒阳性患者现在的预期寿命更长。然而，他们现在在一生中患恶性肿瘤的风险增加。
调查感染人类免疫缺陷病毒的患者出现口腔鳞状细胞癌的年龄。
对感染人类免疫缺陷病毒的患者进行前瞻性临床组织病理学审核。
在200例人类免疫缺陷病毒阳性患者中，16例（8%）出现口腔鳞状细胞癌（9名女性和7名男性；年龄范围18 - 43岁，平均年龄31.7岁）。大多数患者（62.5%）患有III期和IV期疾病（肿瘤-淋巴结-转移分期）。倾向于低分化口腔鳞状细胞癌（使用布罗德组织病理学分类）。
与人类免疫缺陷病毒感染相关的口腔鳞状细胞癌似乎在相对年轻的年龄出现。
