Johnson-Davis Kamisha L, Fernelius Colby, Eliason Nathan B, Wilson Andrew, Beddhu Srinivasan, Roberts William L
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Ann Clin Lab Sci. 2011 Fall;41(4):331-9.
Cardiovascular disease causes morbidity and mortality in chronic kidney disease. Increased formation of oxygen-derived radicals can accelerate the development of atherosclerosis. Several studies have shown an imbalance in antioxidant activity, resulting in high oxidative stress and lipid peroxidation, in subjects undergoing hemodialysis.
Eighty-nine subjects with chronic kidney disease and varying degrees of renal impairment, some of who were undergoing peritoneal or hemodialysis, were studied and compared with a group of healthy controls. F2-isoprostanes, selenium, and oxidized low density lipoprotein (LDL) concentrations were used as markers for in vivo oxidative stress; paraoxonase and glutathione peroxidase were used as markers of antioxidant activity.
We quantified serum F2-isoprostanes, paraoxonase, selenium, oxidized LDL, and RBC glutathione and compared the treatment regimens using post-hoc pair-wise comparisons and Tukey's honest statistical difference. A significant increase in oxidative stress between the hemodialysis and control group was noted. The renal insufficiency and peritoneal dialysis groups showed increased oxidative stress and decreased antioxidant capacity, reaching statistical significance for some serum analytes. Selenium concentrations and oxidized LDL did not vary significantly between the hemodialysis and control groups.
These data suggest that increased oxidative stress and decreased antioxidant activity are associated with declining renal function.
心血管疾病导致慢性肾脏病患者发病和死亡。氧自由基生成增加会加速动脉粥样硬化的发展。多项研究表明，接受血液透析的患者抗氧化活性失衡，导致氧化应激和脂质过氧化水平升高。
对89例患有不同程度肾功能损害的慢性肾脏病患者进行研究，其中部分患者接受腹膜透析或血液透析，并与一组健康对照者进行比较。F2-异前列腺素、硒和氧化型低密度脂蛋白（LDL）浓度用作体内氧化应激的标志物；对氧磷酶和谷胱甘肽过氧化物酶用作抗氧化活性的标志物。
我们对血清F2-异前列腺素、对氧磷酶、硒、氧化型LDL以及红细胞谷胱甘肽进行了定量分析，并使用事后两两比较和Tukey真实统计差异法对治疗方案进行了比较。血液透析组与对照组之间的氧化应激显著增加。肾功能不全组和腹膜透析组的氧化应激增加，抗氧化能力下降，部分血清分析物达到统计学显著水平。血液透析组与对照组之间的硒浓度和氧化型LDL没有显著差异。
这些数据表明，氧化应激增加和抗氧化活性降低与肾功能下降有关。
