Division of Rheumatology, University of Arkansas for Medical Sciences, 4301 West Markham Street, #509, Little Rock, AR 72205, USA.
Mod Rheumatol. 2012 Sep;22(5):778-82. doi: 10.1007/s10165-011-0570-0. Epub 2011 Dec 14.
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in patients with Graves' disease (GD) is linked with the use of anti-thyroid drugs (ATDs). We report the co-occurrence of AAV and GD in a patient that was independent of ATD therapy. A 38-year-old white male presented with systemic symptoms, palpitations, tremors, purpuric skin lesions, and digital pain. Physical examination and biological tests confirmed GD. He quickly developed multiple digital gangrenes and testicular pain/mass. Skin and testicular biopsies showed granulomatous vasculitis of the small- and medium-sized vessels, while his serum contained anti-proteinase-3 antibody.
抗中性粒细胞胞浆抗体相关性血管炎（AAV）与 Graves 病（GD）患者使用抗甲状腺药物（ATD）有关。我们报告了一例 AAV 与 GD 同时发生的病例，与 ATD 治疗无关。一名 38 岁的白人男性出现全身症状、心悸、震颤、紫癜性皮损和手指疼痛。体格检查和生物学检查证实为 GD。他很快出现多处手指坏疽和睾丸疼痛/肿块。皮肤和睾丸活检显示小-中血管肉芽肿性血管炎，同时他的血清中含有抗蛋白酶 3 抗体。
