Ermolaeva S A, Petrov O F, Miller G G, Shaginian I A, Naroditskiĭ B S, Sysoliatina E V, Mukhachev A Ia, Morfill G E, Fortov V E, Grigor'ev A I, Gintsburg A L
Vestn Ross Akad Med Nauk. 2011(10):15-21.
Results of application of LTP at atmospheric pressure as an antibacterial agent during the last decade are considered with reference to physicochemical mechanisms of its bactericidal action. The principles of designing modern LTP sources are described in conjunction with the results of LTP application against pathogenic bacteria in vitro and in biofilms. The possibility to destroy biofilm matrix by LTP is estimated along with the results of its testing for the treatment of acute and chronic wound surfaces. Prospects for the development of "plasma medicine" in this country and abroad are discussed with special emphasis on its advantages, such as the absence of long-acting toxic compounds, small probability of spontaneous mutations accounting for resistance to LTP, relatively low cost of LTP sources, independence of LTP effect of the surface relief, painless application.
本文结合大气压冷等离子体（LTP）杀菌作用的物理化学机制，回顾了过去十年将其作为抗菌剂的应用成果。结合LTP体外及在生物膜中对病原菌的应用结果，阐述了现代LTP源的设计原理。评估了LTP破坏生物膜基质的可能性以及其治疗急慢性创面的测试结果。讨论了国内外“等离子体医学”的发展前景，特别强调了其优势，如不存在长效有毒化合物、自发突变产生LTP抗性的可能性小、LTP源成本相对较低、LTP效应不受表面起伏影响、应用无痛。
