中国广州工人和农民队列研究：低危人群心血管危险因素的不良趋势（1983-1994 年）

Adverse trends of cardiovascular risk factors among low risk populations (1983-1994)--a cohort study of workers and farmers in Guangzhou, China.

机构信息

Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, 96# Dongchuan Road, Guangzhou 510100, Peoples Republic of China.

出版信息

BMC Public Health. 2011 Dec 14;11:931. doi: 10.1186/1471-2458-11-931.

DOI:10.1186/1471-2458-11-931

PMID:22168211

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3264654/

Abstract

BACKGROUND

The levels and trends of cardiovascular risk factors vary greatly throughout China. We examine 10-year trends of cardiovascular risk factors (1983-1994) and the factors related to these trends among low-risk cohorts of workers and farmers in Guangzhou, China.

METHODS

This is a cohort study of 3,131 workers and 3,493 farmers aged 25-64 years at baseline with 10 years of follow-up. We performed a longitudinal analysis to account for the aging of the cohorts and the repeated measures of the same individual.

RESULTS

At baseline the prevalence of overweight (including obese) ranged from 1.0% to 11.8%, hypertension ranged from 3.8% to 10.5%, and mean serum total cholesterol (TC) ranged from 155.4 mg/dl to 187.2 mg/dl. Although prevalence of smoking declined, blood pressure levels and body mass index (BMI) increased significantly, and lipid profiles changed unfavorably during the 10-year follow-ups. The prevalence of hypertension increased from 5.0 percentage points (female farmers) to 12.3 percentage points (male farmers). Mean TC increased significantly (e.g., +22.8 mg/dl and +17.0 mg/dl in male and female farmers, respectively). In the longitudinal data analyses, increase in BMI was associated with increase in blood pressure levels and TC. Significant adverse trends of risk factors persisted after adjustment for aging, education, BMI, smoking, and alcohol intake.

CONCLUSION

Urgent action is needed to prevent and reverse the unhealthy trends occurring among these low risk Chinese workers and farmers.

摘要

背景

中国各地心血管危险因素的水平和趋势差异很大。我们研究了中国广州低危工人和农民队列中 10 年来心血管危险因素（1983-1994 年）的变化趋势及其相关因素。

方法

这是一项对 3131 名工人和 3493 名农民进行的队列研究，他们在基线时年龄为 25-64 岁，随访 10 年。我们进行了纵向分析，以考虑队列的老龄化和同一人群的重复测量。

结果

基线时超重（包括肥胖）的患病率为 1.0%-11.8%，高血压的患病率为 3.8%-10.5%，平均血清总胆固醇（TC）为 155.4mg/dl-187.2mg/dl。虽然吸烟率下降，但血压水平和体重指数（BMI）显著升高，血脂谱在 10 年随访期间也发生了不利变化。高血压的患病率从 5.0%（女性农民）增加到 12.3%（男性农民）。平均 TC 显著增加（例如，男性和女性农民分别增加 22.8mg/dl 和 17.0mg/dl）。在纵向数据分析中，BMI 的增加与血压水平和 TC 的升高有关。在调整年龄、教育程度、BMI、吸烟和饮酒摄入量后，危险因素的不良趋势仍持续存在。