• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高胆固醇血症——非专科医生实用信息

Hypercholesterolaemia - practical information for non-specialists.

作者信息

Soran Handrean, Adam Safwaan, Mohammad Jamal B, Ho Jan H, Schofield Jonathan D, Kwok See, Siahmansur Tarza, Liu Yifen, Syed Akheel A, Dhage Shaishav S, Stefanutti Claudia, Donn Rachelle, Malik Rayaz A, Banach Maciej, Durrington Paul N

机构信息

Cardiovascular Research Group, Faculty of Biology, Medicine & Health, University of Manchester, UK.

Cardiovascular Trials Unit, University Department of Medicine, Manchester University NHS Foundation Trust, Manchester, UK.

出版信息

Arch Med Sci. 2018 Jan;14(1):1-21. doi: 10.5114/aoms.2018.72238. Epub 2017 Dec 19.

DOI:10.5114/aoms.2018.72238
PMID:29379528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5778427/
Abstract

Hypercholesterolaemia is amongst the most common conditions encountered in the medical profession. It remains one of the key modifiable cardiovascular risk factors and there have been recent advances in the risk stratification methods and treatment options available. In this review, we provide a background into hypercholesterolaemia for non-specialists and consider the merits of the different risk assessment tools available. We also provide detailed considerations as to: i) when to start treatment, ii) what targets to aim for and iii) the role of low density lipoprotein cholesterol.

摘要

高胆固醇血症是医疗行业中最常见的病症之一。它仍然是主要的可改变心血管危险因素之一，并且在风险分层方法和可用治疗选择方面最近有了进展。在本综述中，我们为非专业人士提供高胆固醇血症的背景知识，并考虑现有不同风险评估工具的优点。我们还详细考虑了以下方面：i）何时开始治疗，ii）目标值是多少，以及iii）低密度脂蛋白胆固醇的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/972c9b036f7b/AMS-14-31295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/1da922c6c78b/AMS-14-31295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/923e581308f4/AMS-14-31295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/5e0245cdb9b9/AMS-14-31295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/849eac264ef3/AMS-14-31295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/a923aaa53869/AMS-14-31295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/972c9b036f7b/AMS-14-31295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/1da922c6c78b/AMS-14-31295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/923e581308f4/AMS-14-31295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/5e0245cdb9b9/AMS-14-31295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/849eac264ef3/AMS-14-31295-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/a923aaa53869/AMS-14-31295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc18/5778427/972c9b036f7b/AMS-14-31295-g006.jpg

相似文献

1
Hypercholesterolaemia - practical information for non-specialists.高胆固醇血症——非专科医生实用信息
Arch Med Sci. 2018 Jan;14(1):1-21. doi: 10.5114/aoms.2018.72238. Epub 2017 Dec 19.
2
Advances in familial hypercholesterolaemia in children.儿童家族性高胆固醇血症的研究进展。
Lancet Child Adolesc Health. 2021 Sep;5(9):652-661. doi: 10.1016/S2352-4642(21)00095-X. Epub 2021 Jun 11.
3
Microsomal triglyceride transfer protein inhibitor (lomitapide) efficacy in the treatment of patients with homozygous familial hypercholesterolaemia.微粒体甘油三酯转移蛋白抑制剂（洛美他派）治疗纯合子家族性高胆固醇血症患者的疗效。
Eur J Prev Cardiol. 2020 Jan;27(2):157-165. doi: 10.1177/2047487319870007. Epub 2019 Aug 12.
4
How to implement clinical guidelines to optimise familial hypercholesterolaemia diagnosis and treatment.如何实施临床指南以优化家族性高胆固醇血症的诊断和治疗。
Atheroscler Suppl. 2017 Apr;26:25-35. doi: 10.1016/S1567-5688(17)30022-3.
5
Prevention of cardiovascular disease in patients with familial hypercholesterolaemia: The role of PCSK9 inhibitors.家族性高胆固醇血症患者的心血管疾病预防：PCSK9 抑制剂的作用。
Eur J Prev Cardiol. 2017 Sep;24(13):1383-1401. doi: 10.1177/2047487317717346. Epub 2017 Jun 23.
6
Homozygous familial hypercholesterolaemia: update on management.纯合子家族性高胆固醇血症：管理进展
Paediatr Int Child Health. 2016 Nov;36(4):243-247. doi: 10.1080/20469047.2016.1246640.
7
High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study.高脂蛋白(a)作为临床家族性高胆固醇血症的可能病因：一项前瞻性队列研究。
Lancet Diabetes Endocrinol. 2016 Jul;4(7):577-87. doi: 10.1016/S2213-8587(16)30042-0. Epub 2016 May 13.
8
Lipoprotein (a) in familial hypercholesterolaemia.家族性高胆固醇血症中的脂蛋白(a)。
Curr Opin Lipidol. 2022 Aug 1;33(4):257-263. doi: 10.1097/MOL.0000000000000839.
9
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society.纯合子家族性高胆固醇血症：临床医生提高检测和临床管理水平的新见解与指南。欧洲动脉粥样硬化学会家族性高胆固醇血症共识小组的立场文件。
Eur Heart J. 2014 Aug 21;35(32):2146-57. doi: 10.1093/eurheartj/ehu274. Epub 2014 Jul 22.
10
Familial hypercholesterolaemia.家族性高胆固醇血症
Curr Opin Cardiol. 2014 Jul;29(4):381-8. doi: 10.1097/HCO.0000000000000083.

引用本文的文献

1
Association of PRDM16 rs12409277 and CtBP2 rs1561589 gene polymorphisms with lipid profile of adolescents.PRDM16基因rs12409277和CtBP2基因rs1561589多态性与青少年血脂水平的关联
Arch Med Sci. 2021 Jan 8;19(3):593-599. doi: 10.5114/aoms/113174. eCollection 2023.
2
Severe Hypertriglyceridaemia and Chylomicronaemia Syndrome-Causes, Clinical Presentation, and Therapeutic Options.严重高甘油三酯血症和乳糜微粒血症综合征——病因、临床表现及治疗选择
Metabolites. 2023 Apr 30;13(5):621. doi: 10.3390/metabo13050621.
3
Protein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies (PCSK9mab) in Clinical Practice at Secondary Care - Real World Multicentre Experience.

本文引用的文献

1
Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.撤稿与重新发表：地中海饮食对心血管疾病的一级预防。《新英格兰医学杂志》2013年；368卷：1279 - 1290页。
N Engl J Med. 2018 Jun 21;378(25):2441-2442. doi: 10.1056/NEJMc1806491. Epub 2018 Jun 13.
2
Effect of Roux-en-Y Bariatric Surgery on Lipoproteins, Insulin Resistance, and Systemic and Vascular Inflammation in Obesity and Diabetes.Roux-en-Y减肥手术对肥胖症和糖尿病患者脂蛋白、胰岛素抵抗以及全身和血管炎症的影响。
Front Immunol. 2017 Nov 15;8:1512. doi: 10.3389/fimmu.2017.01512. eCollection 2017.
3
二级医疗临床实践中使用的9型枯草杆菌蛋白酶/克新蛋白酶蛋白转化酶单克隆抗体（PCSK9单克隆抗体）——真实世界多中心经验
Cureus. 2022 Dec 28;14(12):e33044. doi: 10.7759/cureus.33044. eCollection 2022 Dec.
4
Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis.家族性高胆固醇血症作为动脉粥样硬化的一个易感因素。
Biomedicines. 2022 Oct 20;10(10):2639. doi: 10.3390/biomedicines10102639.
5
Cardiovascular risk and metabolic profile of Polish citizens from Lower Silesia. First signs of metabolic crisis?下西里西亚波兰公民的心血管风险和代谢状况。代谢危机的最初迹象？
Arch Med Sci. 2020 Oct 14;18(3):617-623. doi: 10.5114/aoms.2020.99922. eCollection 2022.
6
Comparison of low-density lipoprotein cholesterol level calculated using the modified Martin/Hopkins estimation or the Friedewald formula with direct homogeneous assay measured low-density lipoprotein cholesterol.使用改良的Martin/Hopkins估算方法或Friedewald公式计算的低密度脂蛋白胆固醇水平与直接匀相测定法测得的低密度脂蛋白胆固醇水平的比较。
Arch Med Sci. 2020 Aug 3;18(3):577-586. doi: 10.5114/aoms.2020.97847. eCollection 2022.
7
Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies.来自LIPIDOGRAM2015和LIPIDOGEN2015研究的全国性筛查分析的设计与原理
Arch Med Sci. 2020 Jun 4;18(3):604-616. doi: 10.5114/aoms.2020.96052. eCollection 2022.
8
The role of statins in lung cancer.他汀类药物在肺癌中的作用。
Arch Med Sci. 2021 Mar 18;18(1):141-152. doi: 10.5114/aoms/123225. eCollection 2022.
9
: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits.具有潜在健康益处的生物活性植物化学物质宝库。
Evid Based Complement Alternat Med. 2022 Jan 18;2022:4586318. doi: 10.1155/2022/4586318. eCollection 2022.
10
The effect of camelina oil (α-linolenic acid) and canola oil (oleic acid) on lipid profile, blood pressure, and anthropometric parameters in postmenopausal women.亚麻荠油（α-亚麻酸）和菜籽油（油酸）对绝经后女性血脂、血压及人体测量参数的影响。
Arch Med Sci. 2020 Mar 31;17(6):1566-1574. doi: 10.5114/aoms.2020.94033. eCollection 2021.
Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
临床实践中的降脂营养保健品：国际脂质专家小组的立场文件
Arch Med Sci. 2017 Aug;13(5):965-1005. doi: 10.5114/aoms.2017.69326. Epub 2017 Aug 4.
4
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.PCSK9 抑制剂依洛尤单抗降低 LDL-胆固醇水平的临床疗效和安全性：FOURIER 试验的预先设定的次要分析。
Lancet. 2017 Oct 28;390(10106):1962-1971. doi: 10.1016/S0140-6736(17)32290-0. Epub 2017 Aug 28.
5
Very low LDL-cholesterol concentrations achieved: which target is next?实现了极低的低密度脂蛋白胆固醇浓度：下一个目标是什么？
Lancet. 2017 Oct 28;390(10106):1930-1931. doi: 10.1016/S0140-6736(17)32292-4. Epub 2017 Aug 28.
6
Optimizing Cholesterol Treatment in Patients With Muscle Complaints.优化有肌肉不适症状患者的胆固醇治疗。
J Am Coll Cardiol. 2017 Sep 5;70(10):1290-1301. doi: 10.1016/j.jacc.2017.07.752.
7
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.载脂蛋白 AI 模拟肽（Anacetrapib）在动脉粥样硬化性血管疾病患者中的作用。
N Engl J Med. 2017 Sep 28;377(13):1217-1227. doi: 10.1056/NEJMoa1706444. Epub 2017 Aug 28.
8
Cognitive Function in a Randomized Trial of Evolocumab.依洛尤单抗的随机临床试验中的认知功能。
N Engl J Med. 2017 Aug 17;377(7):633-643. doi: 10.1056/NEJMoa1701131.
9
PCSK9 inhibitors - from discovery of a single mutation to a groundbreaking therapy of lipid disorders in one decade.前蛋白转化酶枯草溶菌素9（PCSK9）抑制剂——从单一突变的发现到十年内脂质紊乱的突破性治疗。
Arch Med Sci. 2017 Jun;13(4):914-929. doi: 10.5114/aoms.2017.65239. Epub 2017 Jan 19.
10
Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia.微粒体甘油三酯转运蛋白抑制剂洛美他派治疗纯合子家族性高胆固醇血症患者的长期疗效和安全性
Circulation. 2017 Jul 18;136(3):332-335. doi: 10.1161/CIRCULATIONAHA.117.028208.