[1988年版成人正常肺功能预测方程在上海的适用性]

[The applicability of the 1988 version of the prediction equations for adult normal lung function in Shanghai].

作者信息

Zhao Rong-ya, Zhu Lei, Li Li, Chen Qi, Yang Yan-jie

机构信息

Department of Respiratory Medicine, Zhongshan Hospital, Shanghai, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2011 Aug;34(8):586-9.

PMID:22168980

Abstract

OBJECTIVE

To collect current information of normal adult pulmonary function in Shanghai, and to verify the applicability of the prediction equations for pulmonary function parameters established in 1988.

METHODS

Subjects who underwent routine physical check-up were initially screened in Zhongshan Hospital from Jun. 2009 to Feb. 2010. Those who met the enrollment criteria were asked to take pulmonary function tests. A total of 240 subjects with normal pulmonary function and 120 subjects with mild small airway abnormalities were enrolled in this study according to the prediction equations established in 1988. The age of these subjects ranged from 19 to 83 years old, with a mean age of (42 ± 12) years. All subjects were assigned into 6 groups according to their age, with 60 subjects (30 males, 30 females) in each group. Pulmonary function parameters were collected, including VC, FVC, FEV(1), FEV(1)/FVC, PEF, FEF(25%), FEF(50%), FEF(75%), RV, FRC, TLC, RV/TLC, D(LCO) and KCO. New prediction equations for the above 14 parameters were established by multiple regression analysis. The parameters of anthropometry were introduced into the new and the 1988 prediction equations to get 2 groups of prediction values. Comparison of variance and correlation analysis between the new and the old prediction values were conducted.

RESULTS

New prediction equations for normal adult pulmonary function parameters in Shanghai were established. The actually measured parameters were very close to the predicted values: VC (L) 3.6 ± 0.8 vs 3.6 ± 0.8, FVC (L) 3.5 ± 0.9 vs 3.5 ± 0.8, FEV(1) (L) 3.0 ± 0.8 vs 3.0 ± 0.7, FEV(1)/FVC (%) 83.8 ± 3.1 vs 83.3 ± 2.6, PEF (L/s) 7.7 ± 1.9 vs 7.5 ± 1.6, FEF(25%) (L/s) 6.8 ± 1.7 vs 6.7 ± 1.2, FEF(50%) (L/s) 4.0 ± 0.8 vs 3.9 ± 0.7, FEF(75%) (L/s) 1.5 ± 0.7 vs 1.5 ± 0.6, RV (L) 1.6 ± 0.4 vs 1.6 ± 0.3, FRC (L) 2.8 ± 0.4 vs 2.9 ± 0.4, TLC (L) 5.0 ± 1.0 vs 5.0 ± 0.9, RV/TLC (%) 33.1 ± 4.6 vs 32.7 ± 4.5, D(LCO) (ml×min(-1)×mm Hg(-1), 1 mm Hg = 0.133 kPa) 21.2 ± 5.0 vs 21.2 ± 4.3, KCO (ml×min(-1)×mm Hg(-1)) 4.4 ± 0.7 vs 4.5 ± 0.4 (t = -0.856 - 1.673, all P > 0.05). Except D(LCO) and KCO, there was a significant positive correlation between each pair of the predicted values (r = 0.966 - 0.989, all P < 0.01), and the variance between each pair of predicted values was within 5%.

CONCLUSION

The prediction equations for normal adult pulmonary function parameters established in 1988 is still valid currently for the population in Shanghai.

摘要

目的

收集上海正常成年人群的肺功能现状资料，验证1988年建立的肺功能参数预测方程的适用性。

方法

2009年6月至2010年2月在中山医院对接受常规体检的受试者进行初步筛选。符合纳入标准者进行肺功能检测。根据1988年建立的预测方程，本研究共纳入240例肺功能正常受试者和120例轻度小气道异常受试者。这些受试者年龄在19至83岁之间，平均年龄为（42±12）岁。所有受试者按年龄分为6组，每组60例（男30例，女30例）。收集肺功能参数，包括肺活量（VC）、用力肺活量（FVC）、第1秒用力呼气容积（FEV₁）、FEV₁/FVC、呼气峰值流速（PEF）、25%肺活量最大呼气流量（FEF₂₅%）、50%肺活量最大呼气流量（FEF₅₀%）、75%肺活量最大呼气流量（FEF₇₅%）、残气量（RV）、功能残气量（FRC）、肺总量（TLC）、RV/TLC、一氧化碳弥散量（Dₗco）和一氧化碳弥散系数（KCO）。通过多元回归分析建立上述14个参数的新预测方程。将人体测量学参数代入新的和1988年的预测方程，得到两组预测值。对新旧预测值进行方差比较和相关性分析。

结果

建立了上海正常成年人群肺功能参数的新预测方程。实际测量参数与预测值非常接近：VC（L）3.6±0.8对3.6±0.8，FVC（L）3.5±0.9对3.5±0.8，FEV₁（L）3.0±0.8对3.0±0.7，FEV₁/FVC（%）83.8±3.1对83.3±2.6，PEF（L/s）7.7±1.9对7.5±1.6，FEF₂₅%（L/s）6.8±1.7对6.7±1.2，FEF₅₀%（L/s）4.0±0.8对3.9±0.7，FEF₇₅%（L/s）1.5±0.7对1.5±0.6，RV（L）1.6±0.4对1.6±0.3，FRC（L）2.8±0.4对2.9±0.4，TLC（L）5.0±1.0对5.0±0.9，RV/TLC（%）33.1±4.6对32.7±4.5，Dₗco（ml·min⁻¹·mmHg⁻¹，1 mmHg = 0.133 kPa）21.2±5.0对21.2±4.3, KCO（ml·min⁻¹·mmHg⁻¹）4.4±0.7对4.5±0.4（t = -0.856～-1.673，均P>0.05）。除Dₗco和KCO外，各对预测值之间均呈显著正相关（r = 0.966～0.989，均P<0.01），各对预测值之间的方差在5%以内。