8至18岁健康伊朗年轻人肺功能值的预测方程。

Prediction equations for pulmonary function values in healthy young Iranians aged 8-18 years.

作者信息

Boskabady Mohammad Hossein, Tashakory Abulghasem, Mazloom Reza, Ghamami Gity

机构信息

Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Respirology. 2004 Nov;9(4):535-42. doi: 10.1111/j.1440-1843.2004.00623.x.

DOI:10.1111/j.1440-1843.2004.00623.x

PMID:15612967

Abstract

OBJECTIVE

Pulmonary function test (PFT) variables are dependent on height, age and gender. In addition, there is evidence of PFT variation in different ethnic groups. Prediction equations for PFT from a healthy, non-smoking, urban young population in the city of Mashhad (north-east Iran) have been derived.

METHODOLOGY

Prediction equations for normal pulmonary function were derived from 336 healthy, non-smoking subjects, including 187 males (height 103-188.5 cm) and 149 females (height 104-183 cm) aged 8-18 years. The subjects underwent measurement of spirometric flow and volume. The following variables were measured: FVC, FEV1, maximal mid-expiratory flow (MMEF), PEF, maximal expiratory flow at 75, 50 and 25% of the FVC (MEF75, MEF50, and MEF25, respectively), tidal volume (VT), inspiratory reserve volume (IRV), expiratory reserve volume (ERV), inspiratory capacity (IC), and vital capacity (VC). Regression analysis using height and age as independent variables was applied to provide predicted values for both genders.

RESULTS

There were positive correlations for each pulmonary function variable with height and age. The largest positive correlations were found for FEV1 with height and age, in both genders. Comparison of PFT variables derived from the equations obtained in the present study showed significant differences to those calculated from several previously published equations (P < 0.001 for most variables). For example, the values of FVC and FEV1 derived from the equations obtained in the present study were 2.83 +/- 0.99 and 2.50 +/- 0.89 for males, and 2.41 +/- 0.54 and 2.19 +/- 0.53 for females, while the values derived from the equations of the European Community for Steel and Coal study were 3.12 +/- 1.06 and 2.62 +/- 0.89 for males and 2.79 +/- 0.67 and 3.35 +/- 0.57 for females, respectively.

CONCLUSIONS

A set of PFT reference values and prediction equations for both genders has been derived using a relatively large, healthy, non-smoking Iranian young population, and has generated results that differ from several other prediction equations.

摘要

目的

肺功能测试（PFT）变量取决于身高、年龄和性别。此外，有证据表明不同种族群体的肺功能存在差异。已得出伊朗东北部马什哈德市健康、不吸烟的城市年轻人群的肺功能预测方程。

方法

从336名健康、不吸烟的受试者中得出正常肺功能的预测方程，其中包括187名男性（身高103 - 188.5厘米）和149名女性（身高104 - 183厘米），年龄在8至18岁之间。受试者接受了肺活量测定流量和容积的测量。测量了以下变量：用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、最大呼气中期流量（MMEF）、呼气峰值流量（PEF）、FVC的75%、50%和25%时的最大呼气流量（分别为MEF75、MEF50和MEF25）、潮气量（VT）、吸气储备容积（IRV）、呼气储备容积（ERV）、吸气容量（IC）和肺活量（VC）。以身高和年龄作为自变量进行回归分析，以提供男女两性的预测值。

结果

每个肺功能变量与身高和年龄均呈正相关。在男女两性中，FEV1与身高和年龄的正相关性最大。将本研究中获得的方程得出的PFT变量与先前发表的几个方程计算得出的变量进行比较，结果显示存在显著差异（大多数变量P < 0.001）。例如，本研究中获得的方程得出的男性FVC和FEV1值分别为2.83±0.99和2.50±0.89，女性为2.41±0.54和2.19±0.53，而欧洲煤钢共同体研究方程得出的男性值分别为3.12±1.06和2.62±0.89，女性为2.79±0.67和3.35±0.57。