肿瘤坏死因子超家族在炎症性疾病中的作用：从基础研究到临床应用
TNF superfamily in inflammatory disease: translating basic insights.
机构信息
La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, La Jolla, CA 92037, USA.
出版信息
Trends Immunol. 2012 Mar;33(3):144-52. doi: 10.1016/j.it.2011.10.004. Epub 2011 Dec 13.
Abstract
The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions including promoting cellular differentiation, survival, and production of inflammatory cytokines and chemokines. Emerging data show that TNFSF ligand-receptor signaling pathways are active in inflammatory and autoimmune disease. Furthermore, several genetic polymorphisms in TNFSF and TNFRSF associate with susceptibility to developing disease. Here, we examine recent data regarding the potential of these molecules as targets for therapy of autoimmune and inflammatory disease.
摘要
肿瘤坏死因子 (TNF) 和 TNF 受体超家族 (TNFSF 和 TNFRSF) 由大约 50 种膜和可溶性蛋白组成，可调节细胞功能。这些分子中的大多数由免疫系统的细胞表达或可以靶向这些细胞，它们具有广泛的作用，包括促进细胞分化、存活以及细胞因子和趋化因子的产生。新出现的数据表明，TNFSF 配体-受体信号通路在炎症和自身免疫性疾病中活跃。此外，TNFSF 和 TNFRSF 中的几个遗传多态性与易患疾病有关。在这里，我们研究了这些分子作为治疗自身免疫性和炎症性疾病的靶点的潜在性的最新数据。
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