肿瘤坏死因子/TNF 受体超家族：自身免疫性疾病的治疗靶点。
The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases.
机构信息
Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.
出版信息
Clin Exp Immunol. 2011 May;164(2):145-57. doi: 10.1111/j.1365-2249.2011.04375.x. Epub 2011 Mar 14.
Abstract
Autoimmune diseases are characterized by the body's ability to mount immune attacks on self. This results from recognition of self-proteins and leads to organ damage due to increased production of pathogenic inflammatory molecules and autoantibodies. Over the years, several new potential therapeutic targets have been identified in autoimmune diseases, notable among which are members of the tumour necrosis factor (TNF) superfamily. Here, we review the evidence that certain key members of this superfamily can augment/suppress autoimmune diseases.
摘要
自身免疫性疾病的特征是身体能够对自身发动免疫攻击。这是由于对自身蛋白的识别引起的，导致器官损伤是由于致病性炎症分子和自身抗体的产生增加。多年来，已经在自身免疫性疾病中鉴定出了几个新的潜在治疗靶点，其中值得注意的是肿瘤坏死因子（TNF）超家族的成员。在这里，我们回顾了该超家族的某些关键成员可以增强/抑制自身免疫性疾病的证据。
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