Hellenthal Femke A M V I, Pulinx Bianca, Welten Rob J Th J, Teijink Joep A W, van Dieijen-Visser Marja P, Wodzig Will K W H, Schurink Geert Willem H
Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
J Surg Res. 2012 Aug;176(2):672-8. doi: 10.1016/j.jss.2011.09.040. Epub 2011 Oct 11.
Abdominal aortic aneurysm (AAA) is a degenerative disease of the abdominal aorta leading to progressive dilatation, intra-luminal thrombus (ILT) formation, and rupture. Understanding the natural history of AAA is essential, because different processes and, therefore, different biomarkers, could be involved at each stage of disease progression. The purpose of the present study was to investigate the relationship between systemic expression of biomarkers of inflammation and extracellular matrix remodeling and aneurysm size in AAA patients.
All consecutive patients admitted to the (out-) patient clinic of the surgical department of two large community centers were prospectively included. Patients were divided into three groups based on their aneurysm diameter: small (30-44 mm; n = 59), medium-sized (45-54 mm; n = 64) or large (≥ 55 mm; n = 95) AAA. Linear regression modeling showed that age and serum hsCRP concentration were positively associated, whereas serum HDL and IgG concentrations were negatively associated with aneurysm size. This regression model was corrected for possible bias due to statin use and center of inclusion; and also indicated that in general men have larger aneurysms compared with women.
Different aneurysm sizes showed different expression pattern of HDL, IgG, and hsCRP. These biomarkers may be useful in predicting AAA progression.
腹主动脉瘤（AAA）是一种腹主动脉退行性疾病，可导致主动脉逐渐扩张、管腔内血栓（ILT）形成及破裂。了解AAA的自然病程至关重要，因为在疾病进展的每个阶段可能涉及不同的过程，进而涉及不同的生物标志物。本研究的目的是探讨AAA患者炎症生物标志物的全身表达和细胞外基质重塑与动脉瘤大小之间的关系。
前瞻性纳入两家大型社区中心外科门诊（包括门诊和住院）的所有连续患者。根据动脉瘤直径将患者分为三组：小动脉瘤（30 - 44 mm；n = 59）、中等大小动脉瘤（45 - 54 mm；n = 64）或大动脉瘤（≥ 55 mm；n = 95）。线性回归模型显示，年龄和血清hsCRP浓度呈正相关，而血清HDL和IgG浓度与动脉瘤大小呈负相关。该回归模型对因使用他汀类药物和纳入中心可能产生的偏差进行了校正；并且还表明，总体而言男性的动脉瘤比女性更大。
不同大小的动脉瘤显示出HDL、IgG和hsCRP的不同表达模式。这些生物标志物可能有助于预测AAA的进展。
