Flondell-Sité Despina, Lindblad Bengt, Kölbel Tilo, Gottsäter Anders
University of Lund, Vascular Centre, Malmö University Hospital, S-205 02 Malmö, Sweden.
Cytokine. 2009 May;46(2):211-5. doi: 10.1016/j.cyto.2009.01.007. Epub 2009 Feb 28.
The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth.
Prospectively 360 AAA-patients and an age and sex-matched healthy control group (n=219) were analyzed. AAA-patients were divided in three groups according to AAA-diameter (small <45 mm, n=122, medium 45-55 mm, n=108, and large >55 mm, n=130). Associated diseases, blood pressures and routine laboratory markers were analyzed. Additionally we evaluated endothelin (ET)-1, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, activated protein C-protein C inhibitor (APC-PCI) complex, and CD40 ligand. Groups were compared with the Kruskall-Wallis test and the Mann-Whitney U test.
Of routine markers platelet count was lower (p=0.0006) and creatinine level was higher (p=0.028) in patients with large AAA. Almost all non-routine markers analyzed were highly elevated in AAA-patients compared to the control group. IL-6 (p=0.0002) and thrombin activation measured as APC-PCI (p<0.0001) increased depending on the size of AAA.
Many of the analyzed biomarkers were markedly increased in AAA-patients and some were also related to aneurysm size. Whether any of the markers is also associated with aneurysm growth rate should be further evaluated.
腹主动脉瘤（AAA）的病因包括动脉粥样硬化、炎症、免疫和凝血机制。本研究的目的是评估这些机制中一些机制的标志物与AAA大小之间的关联，以便确定以后可能与动脉瘤生长相关进行评估的标志物。
前瞻性分析了360例AAA患者和一个年龄及性别匹配的健康对照组（n = 219）。根据AAA直径将AAA患者分为三组（小<45 mm，n = 122；中45 - 55 mm，n = 108；大>55 mm，n = 130）。分析相关疾病、血压和常规实验室标志物。此外，我们评估了内皮素（ET）-1、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、活化蛋白C - 蛋白C抑制剂（APC - PCI）复合物和CD40配体。采用Kruskal - Wallis检验和Mann - Whitney U检验对各组进行比较。
在大AAA患者中，常规标志物血小板计数较低（p = 0.0006），肌酐水平较高（p = 0.028）。与对照组相比，几乎所有分析的非常规标志物在AAA患者中均显著升高。IL - 6（p = 0.0002）和以APC - PCI衡量的凝血酶激活（p<0.0001）随AAA大小增加而升高。
许多分析的生物标志物在AAA患者中显著升高，有些还与动脉瘤大小有关。这些标志物是否也与动脉瘤生长速率相关应进一步评估。
