Diallo Mamadou, Zheng Yuhuang, Chen Xia, He Yan, Zhou Huaying, Chen Zi
AIDS Research Laboratory, Department of Infectious Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov;36(11):1037-45. doi: 10.3969/j.issn.1672-7347.2011.11.002.
Although highly active antiretroviral therapy (HAART) can effectively reduce the HIV replication, complete recovery of CD4(+) T cells does not always occur, even among patients with high virological control. Current researches on γ-chain cytokines have understood the biology and their crucial roles in initiating, maintaining, and regulating the immunologic homeostasis and the inflammatory processes. Due to the multiple functions such as the regulatory and effector cellular function in healthy and disease state, these molecules, their receptors, and their signal transduction pathways are promising candidates for therapeutic interference. The common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 are primary regulators of T cell homeostasis and thus have been considered prime immunotherapeutic candidates, both for increasing T cell levels/function and augmenting vaccine-elicited viral-specific T cell responses in immunocompromised AIDS patients. The Objective of this review is to update the role of the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 in HIV AIDS pathogenesis.
尽管高效抗逆转录病毒疗法（HAART）能有效降低HIV复制，但即使在病毒学控制良好的患者中，CD4(+) T细胞也并非总能完全恢复。目前关于γ链细胞因子的研究已经了解了它们在启动、维持和调节免疫稳态及炎症过程中的生物学特性及其关键作用。由于这些分子在健康和疾病状态下具有调节和效应细胞功能等多种功能，它们及其受体以及信号转导途径是有前景的治疗干预候选对象。常见的γ链细胞因子白细胞介素-2（IL-2）、白细胞介素-7（IL-7）、白细胞介素-15（IL-15）和白细胞介素-21（IL-21）是T细胞稳态的主要调节因子，因此被视为主要的免疫治疗候选对象，既能提高免疫功能低下的艾滋病患者的T细胞水平/功能，又能增强疫苗引发的病毒特异性T细胞反应。本综述的目的是更新常见γ链细胞因子IL-2、IL-7、IL-15和IL-21在HIV/AIDS发病机制中的作用。
