Li Xiejia, Xiao Li, Sun Lin, Liu Fuyou
Department of Nephropathy, Second Xiangya Hospital; Renal Institute, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov;36(11):1120-4. doi: 10.3969/j.issn.1672-7347.2011.11.016.
Immunoglobulin A nephropathy (IgAN), which can develop into end-stage renal disease, is the most common primary glomerulonephritis. The pathogenesis of IgAN is not clear. Many studies have confirmed that genetic susceptibility is associated with IgAN, and it belongs to polygenic disease. Some studies have found that IgAN is associated with chromosome 6q22-23, 2q36 by linkage analysis, and several candidate genes have been confirmed to be associated with IgAN, such as angiotensin converting enzyme, Fc fragment of IgA receptor, human leukocyte antigen. In recent years, as the progression of molecular genetics and the Human Genome Project, more attention has been paid to the role of genetic factors in the pathogenesis of IgAN.
免疫球蛋白A肾病（IgAN）是最常见的原发性肾小球肾炎，可发展为终末期肾病。IgAN的发病机制尚不清楚。许多研究证实，遗传易感性与IgAN相关，它属于多基因疾病。一些研究通过连锁分析发现IgAN与6号染色体q22 - 23、2q36相关，并且已经证实几个候选基因与IgAN相关，如血管紧张素转换酶、IgA受体的Fc片段、人类白细胞抗原。近年来，随着分子遗传学和人类基因组计划的进展，遗传因素在IgAN发病机制中的作用受到了更多关注。
