Department of Dermatology, University of Heidelberg, Germany.
Acta Derm Venereol. 2012 Mar;92(2):152-5. doi: 10.2340/00015555-1226.
Congenital melanocytic naevi can give rise to secondary melanocytic tumours, such as proliferative nodules and malignant melanoma. The clinical and histological features of both lesions may be nearly identical, which makes an unequivocal diagnosis impossible. In particular, it is difficult to differentiate clearly between benign and malignant proliferation in infants with secondary melanocytic proliferation. Reports on melanocytic proliferation and malignant melanoma within the paediatric age-group are very rare. There is limited expert knowledge on this subject and little is known about prognosis and outcome. We report here a case of an infant with an unusual transformation of a congenital spindle cell naevus of the umbilical region, and discuss clinical, histological and genomic criteria.
先天性黑素细胞痣可引起继发性黑素细胞肿瘤，如增殖性结节和恶性黑色素瘤。这两种病变的临床和组织学特征可能几乎相同，这使得明确的诊断变得不可能。特别是，在患有继发性黑素细胞增殖的婴儿中，良性和恶性增殖之间很难明确区分。关于儿科年龄组内黑素细胞增殖和恶性黑色素瘤的报告非常罕见。关于这个问题，专家的知识有限，对预后和结果知之甚少。我们在此报告一例脐区先天性梭形细胞痣的罕见恶变，并讨论临床、组织学和基因组标准。
