Arnoldi R, Leva E, Macchini F, Di Cesare A, Colnaghi M, Fumagalli M, Mosca F, Torricelli M
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pediatric Surgery, Milano, Italy.
Eur J Pediatr Surg. 2011 Dec;21(6):395-8. doi: 10.1055/s-0031-1291301. Epub 2011 Dec 14.
Delayed meconium passage, typical of premature newborns, is a predisposing condition for bowel perforation with a significant risk of morbidity and mortality.
A retrospective study was undertaken to verify the entity of the disease, assess the average time to meconium passage in a neonatal population of very low birth weight (VLBW) infants, and identify associated risk factors.
The time of first stool passage was studied in 110 VLBW infants (weighing less than 1500 g at birth). Their perinatal features, clinical course, and treatment were reviewed and studied retrospectively.
Delayed meconium passage was recorded in 81% of this group. Patent ductus arteriosus, mechanical ventilation and uteroplacental insufficiency were significantly associated with delayed passage. An inverse relationship between gestational age, birth weight and meconium passage was found. Bowel perforation occurred in 4.5% of this neonatal population with a mortality of 50%.
In very low birth weight infants delay in the passage of the first stool is common. Perforation in these patients may represent a fatal event, and procedures such as daily rectal enemas, which can prevent this complication, must be applied.
胎粪排出延迟是早产儿的典型表现，是肠穿孔的诱发因素，具有较高的发病和死亡风险。
进行一项回顾性研究，以核实该病的实际情况，评估极低出生体重（VLBW）新生儿群体中胎粪排出的平均时间，并确定相关风险因素。
对110例极低出生体重婴儿（出生体重低于1500克）首次排便时间进行研究。回顾并回顾性研究了他们的围产期特征、临床过程和治疗情况。
该组81%记录有胎粪排出延迟。动脉导管未闭、机械通气和子宫胎盘功能不全与排出延迟显著相关。发现胎龄、出生体重与胎粪排出之间呈负相关。该新生儿群体中4.5%发生肠穿孔，死亡率为50%。
在极低出生体重婴儿中，首次排便延迟很常见。这些患者的穿孔可能是致命事件，必须采用如每日直肠灌肠等可预防该并发症的措施。
