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异烟肼引起的肺部浸润和发热。

Pulmonary infiltrates and fever induced by isoniazid.

作者信息

Salomaa E R, Ruokonen E L, Tevola K, Tala E

机构信息

Department of Diseases of the Chest, University Central Hospital of Turku, Preitilä, Finland.

出版信息

Postgrad Med J. 1990 Aug;66(778):647-9. doi: 10.1136/pgmj.66.778.647.

Abstract

An 88 year old woman with bacteriologically confirmed pulmonary tuberculosis was first treated with isoniazid, rifampicin and pyrazinamide. Two weeks later she developed pulmonary infiltrates with fever. A drug-induced reaction was suspected but the reaction recurred three times until isoniazid was identified as the cause. The reaction became worse each time, finally being nearly fatal.

摘要

一名88岁经细菌学确诊为肺结核的女性患者,最初接受异烟肼、利福平及吡嗪酰胺治疗。两周后,她出现肺部浸润并伴有发热。怀疑是药物引起的反应,但该反应反复发作三次,直到确定异烟肼为病因。每次反应都愈发严重,最终几乎致命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654a/2429668/61f507191590/postmedj00164-0061-a.jpg

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本文引用的文献

4
Drug fever due to administration of isoniazid.异烟肼所致药物热
Am Rev Tuberc. 1953 Aug;68(2):249-52. doi: 10.1164/art.1953.68.2.249.
5
Drug fever.药物热
JAMA. 1981 Feb 27;245(8):851-4.
8
Severe febrile reaction to isoniazid.
Chest. 1987 Apr;91(4):620-1. doi: 10.1378/chest.91.4.620.
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Isoniazid-induced interstitial pneumonia.异烟肼所致间质性肺炎。
Respir Med. 1989 Nov;83(6):517-9. doi: 10.1016/s0954-6111(89)80139-8.
10
Drug-induced pulmonary disease. Part I. Patterns of response.
Cleve Clin Q. 1979 Fall;46(3):89-99. doi: 10.3949/ccjm.46.3.89.

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