Salomaa E R, Ruokonen E L, Tevola K, Tala E
Department of Diseases of the Chest, University Central Hospital of Turku, Preitilä, Finland.
Postgrad Med J. 1990 Aug;66(778):647-9. doi: 10.1136/pgmj.66.778.647.
An 88 year old woman with bacteriologically confirmed pulmonary tuberculosis was first treated with isoniazid, rifampicin and pyrazinamide. Two weeks later she developed pulmonary infiltrates with fever. A drug-induced reaction was suspected but the reaction recurred three times until isoniazid was identified as the cause. The reaction became worse each time, finally being nearly fatal.
一名88岁经细菌学确诊为肺结核的女性患者,最初接受异烟肼、利福平及吡嗪酰胺治疗。两周后,她出现肺部浸润并伴有发热。怀疑是药物引起的反应,但该反应反复发作三次,直到确定异烟肼为病因。每次反应都愈发严重,最终几乎致命。