Most medications can cause fever, with or without concomitant clinical manifestations. The fever may arise from the drug's pharmacologic action, its effects on thermoregulation, a local complication following parenteral administration, or an idiosyncratic response. The most common mechanism is probably an immunologic reaction mediated by drug-induced antibodies. Drug fever may have any pattern; it typically occurs after seven to ten days of treatment and usually resolves within 48 hours of discontinuing the administration. Failure to diagnose drug fever may lead to inappropriate and potentially harmful diagnostic and therapeutic interventions. In suspected cases, it is necessary to discontinue administration of all potentially causative medicines, together or sequentially. Rechallenge with the offending agent will usually cause recurrence of fever within a few hours, confirming the diagnosis.
大多数药物都可能引起发热，无论有无伴随临床表现。发热可能源于药物的药理作用、对体温调节的影响、胃肠外给药后的局部并发症或特异反应。最常见的机制可能是由药物诱导的抗体介导的免疫反应。药物热可能有任何热型；通常在治疗7至10天后出现，停药后48小时内通常消退。未能诊断出药物热可能导致不适当且潜在有害的诊断和治疗干预。在疑似病例中，有必要一起或依次停用所有可能致病的药物。再次使用致病药物通常会在数小时内导致发热复发，从而确诊。
