Restier J, de Carsalade G-Y, Ahmed Abdou M, Valyi L, Cuvelier I, Dauvergne A
Centre hospitalier de Valence, Valence, France.
Bull Soc Pathol Exot. 2012 Feb;105(1):49-57. doi: 10.1007/s13149-011-0198-5. Epub 2011 Dec 14.
In the French island of Mayotte in the Indian Ocean, the health and food situation remains contrasted. For a very long time dry beriberi women in postpartum had been suspected and treated. But in 2004 the first infantile epidemic of beriberi was scientifically authenticated and a program of thiaminic supplementation for the pregnant women and infants was set up. In this context, we describe an epidemic of 11 cases of shoshin beriberi among adults between January 2008 and Februar 2009. Over 11 cases of shoshin beriberi, 5 cases were confirmed biologically and 6 were probable. The sex ratio M/W was 0.37. The median age was 34 years. The clinic picture was typical: severe acute dyspnea, an agitation/drowsiness, right cardiac failure: polynevritis of the lower limbs was noted in 9 cases over 11. Biologically it was characterized by a lactic acidosis (average pH: 7.08, lactates: 12.08 mmol/l). The evolution was favorable in the 8 cases which could benefit from early thiaminic refill. The outbreak of an epidemic of shoshin beriberi among adults mainly in groups not having benefited from supplementation shows the effectiveness of the program but also its limits. We compare our series with others: the period from April to June when the food is less diversified, is confirmed as a higher risk period. The programs of nutritional education must be increased and a B1 vitamin supplementation for broader people during the rain season might be discussed.
在印度洋的法国岛屿马约特岛,健康与食品状况依然呈现出反差。在很长一段时间里,产后妇女的干性脚气病一直受到怀疑并得到治疗。但在2004年,首次婴儿脚气病疫情得到科学证实,一项针对孕妇和婴儿的硫胺补充计划得以设立。在此背景下,我们描述了2008年1月至2009年2月期间11例成人急性爆发性脚气病的疫情。在这11例急性爆发性脚气病病例中,5例经生物学确诊,6例疑似。男女比例为0.37。中位年龄为34岁。临床症状典型:严重急性呼吸困难、烦躁/嗜睡、右心衰竭:11例中有9例出现下肢多发性神经炎。从生物学角度看,其特征为乳酸酸中毒(平均pH值:7.08,乳酸盐:12.08 mmol/L)。8例能够尽早补充硫胺的患者病情转好。主要在未受益于补充计划人群中爆发的成人急性爆发性脚气病疫情,既显示了该计划的有效性,也暴露出其局限性。我们将我们的病例系列与其他病例进行比较:食物种类较少的4月至6月期间被确认为高风险期。必须加强营养教育计划,并且可能需要讨论在雨季为更广泛人群补充维生素B1的问题。