Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
Phytother Res. 2012 Aug;26(8):1126-32. doi: 10.1002/ptr.3681. Epub 2011 Dec 14.
The purpose of this study was to investigate the effect of astaxanthin extracted from Paracoccus carotinifaciens on gastric mucosal damage in murine gastric ulcer models. Mice were pretreated with astaxanthin for 1 h before ulcer induction. Gastric ulcers were induced in mice by oral administration of hydrochloride (HCl)/ethanol or acidified aspirin. The effect of astaxanthin on lipid peroxidation in murine stomach homogenates was also evaluated by measuring the level of thiobarbituric acid reactive substance (TBARS). The free radical scavenging activities of astaxanthin were also measured by electron spin resonance (ESR) measurements. Astaxanthin significantly decreased the extent of HCl/ethanol- and acidified aspirin-induced gastric ulcers. Astaxanthin also decreased the level of TBARS. The ESR measurement showed that astaxanthin had radical scavenging activities against the 1,1-diphenyl-2-picrylhydrazyl radical and the superoxide anion radical. These results suggest that astaxanthin has antioxidant properties and exerts a protective effect against ulcer formation in murine models.
本研究旨在探讨从球形红假单胞菌中提取的虾青素对小鼠胃溃疡模型胃黏膜损伤的影响。在诱导溃疡前，小鼠用虾青素预处理 1 小时。通过口服盐酸（HCl）/乙醇或酸化阿司匹林诱导小鼠胃溃疡。通过测量硫代巴比妥酸反应物质（TBARS）的水平来评估虾青素对小鼠胃匀浆中脂质过氧化的影响。通过电子自旋共振（ESR）测量还测量了虾青素的自由基清除活性。虾青素显著降低了 HCl/乙醇和酸化阿司匹林诱导的胃溃疡的程度。虾青素还降低了 TBARS 的水平。ESR 测量表明，虾青素对 1,1-二苯基-2-苦基肼自由基和超氧阴离子自由基具有自由基清除活性。这些结果表明虾青素具有抗氧化特性，并对小鼠模型中的溃疡形成具有保护作用。
