Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkey.
Department of Nutrition and Dietetics, Faculty of Health Science, University of Health Sciences, 34668 Istanbul, Turkey.
Nutrients. 2024 Oct 10;16(20):3426. doi: 10.3390/nu16203426.
BACKGROUND/OBJECTIVES: Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists.
In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on an ethanol-induced gastric ulcer model were compared during biochemical and histological observations. Sprague-Dawley ( = 64) rats randomly divided into four groups-normal control (vehicle), KO, FO, and ASX groups-received the supplements via the orogastric route at a rate of 2.5% (/) of their daily feed consumption for 4 weeks. Then, ulcer induction was performed with ethanol.
The ulcer group showed increased levels of malondialdehyde (MDA), chemiluminescence (CL), and myeloperoxidase (MPO) activity and decreased levels of glutathione in the gastric tissues. While KO, FO, and ASX supplementation decreased chemiluminescence levels in the ulcer group, only ASX supplementation decreased MDA levels and MPO activity.
In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation.
背景/目的：尽管在溃疡治疗研究方面取得了进展，但仍在寻找预防和治疗溃疡疾病的新的、安全且有效的策略。
在这项研究中，在生化和组织学观察期间，比较了膳食补充磷虾油（KO）、鱼油（FO）和虾青素（ASX）对乙醇诱导的胃溃疡模型的保护作用。将 Sprague-Dawley（n = 64）大鼠随机分为四组-正常对照组（载体）、KO 组、FO 组和 ASX 组-通过口腔途径以其每日饲料摄入量的 2.5%（/）的速率接受补充剂，持续 4 周。然后，用乙醇诱导溃疡。
溃疡组胃组织中丙二醛（MDA）、化学发光（CL）和髓过氧化物酶（MPO）活性升高，谷胱甘肽水平降低。虽然 KO、FO 和 ASX 补充剂降低了溃疡组的化学发光水平，但只有 ASX 补充剂降低了 MDA 水平和 MPO 活性。
总之，KO 或 FO 的补充对乙醇诱导的溃疡损伤具有相似的保护作用，因为它抑制 ROS 的形成并减少脂质过氧化。然而，与 KO 或 FO 补充相比，ASX 补充对实验性乙醇诱导的大鼠胃损伤具有更高的保护作用，因为它抑制 ROS 的形成并减少中性粒细胞浸润和脂质过氧化。
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