Ito M, Suzuki Y, Ishihara M, Suzuki Y
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Eur J Pharmacol. 1998 Aug 7;354(2-3):189-96. doi: 10.1016/s0014-2999(98)00448-8.
We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats. When the free radical-scavenging activity of probucol was measured by an electron spin resonance technique, the agent (10(-5)-10(-3) M) scavenged both superoxide anions and hydroxyl radicals. Oral administration of probucol (250-1000 mg/kg) dose dependently prevented the HCl plus ethanol-induced gastric mucosal injury and the increase in thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the injured mucosa. Repeated oral administration of probucol (250-1000 mg/kg twice daily) dose dependently accelerated the healing of acetic acid-induced gastric ulcers. In addition, probucol already inhibited the increase in the content of thiobarbituric acid-reactive substances in the ulcerated region before the ulcer-healing effect of this agent was recognized. These results suggest that probucol may partly protect gastric mucosa from acute gastric mucosal injury and promote the healing of chronic gastric ulcers by its antioxidant activity.
我们研究了普罗布考（一种具有抗氧化特性的降脂药物）对盐酸加乙醇诱导的大鼠胃黏膜损伤以及对乙酸诱导的大鼠胃溃疡愈合的影响。当用电子自旋共振技术测定普罗布考的自由基清除活性时，该药物（10⁻⁵ - 10⁻³ M）能清除超氧阴离子和羟自由基。口服普罗布考（250 - 1000 mg/kg）剂量依赖性地预防了盐酸加乙醇诱导的胃黏膜损伤以及损伤黏膜中硫代巴比妥酸反应性物质（脂质过氧化指标）的增加。重复口服普罗布考（250 - 1000 mg/kg，每日两次）剂量依赖性地加速了乙酸诱导的胃溃疡的愈合。此外，在该药物的溃疡愈合作用被认识之前，普罗布考就已抑制了溃疡区域硫代巴比妥酸反应性物质含量的增加。这些结果表明，普罗布考可能通过其抗氧化活性部分保护胃黏膜免受急性胃黏膜损伤，并促进慢性胃溃疡的愈合。
