National Institute for Communicable Diseases of the National Health Service, Sandringham, South Africa.
Emerg Infect Dis. 2011 Dec;17(12):2270-6. doi: 10.3201/eid1712.111035.
Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
对 198 株裂谷热病毒分离株和 5 株源自沙特阿拉伯和非洲 16 个国家不同来源的衍生株进行了系统发育关系研究，时间跨度为 67 年（1944-2010 年）。利用 Gn 糖蛋白基因 490 个核苷酸片段的序列数据构建最大似然树，结果表明，95 个独特序列分为 15 个谱系。南非一位可能同时感染活疫苗病毒和野生病毒的患者的 2010 年分离株为重组病毒。文中讨论了大规模使用活疫苗对裂谷热病毒进化的潜在影响。
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