Dongó E, Hornyák I, Benko Zs, Kiss Levente
Semmelweis University Institute of Human Physiology and Clinical Experimental Research, Budapest, Hungary.
Acta Physiol Hung. 2011 Dec;98(4):369-81. doi: 10.1556/APhysiol.98.2011.4.1.
Myocardial infarction is responsible for the majority of cardiovascular mortality and the pathogenesis of myocardial damage during and after the infarction involves reactive oxygen species. Serious efforts are under way to modulate the developing ischemia/reperfusion injury and recently the use of hydrogen sulfide (H2S) emerged as a new possibility. H2S has been best known for decades as a pungent toxic gas in contaminated environmental atmosphere, but it has now been recognized as a novel gasotransmitter in the central nervous and cardiovascular systems, similarly to nitric oxide (NO) and carbon monoxide (CO). This finding prompted the investigation of the potential of H2S as a cardioprotective agent and various in vitro and in vivo results demonstrate that H2S may be of value in cytoprotection during the evolution of myocardial infarction. Although several questions remain to be elucidated about the properties of this new gasotransmitter, increased H2S levels may have therapeutic potential in clinical settings in which ischemia/reperfusion injury is encountered. This review article overviews the current understanding of the effects of this exciting molecule in the setting of myocardial ischemia/reperfusion.
心肌梗死是心血管疾病死亡的主要原因,梗死期间及之后心肌损伤的发病机制涉及活性氧。目前正在努力调节正在发展的缺血/再灌注损伤,最近硫化氢(H2S)的使用成为一种新的可能性。几十年来,H2S在受污染的环境大气中一直作为一种刺鼻的有毒气体为人所知,但现在它已被公认为中枢神经系统和心血管系统中的一种新型气体信号分子,类似于一氧化氮(NO)和一氧化碳(CO)。这一发现促使人们研究H2S作为心脏保护剂的潜力,各种体外和体内研究结果表明,H2S在心肌梗死发展过程中的细胞保护方面可能具有价值。尽管关于这种新的气体信号分子的特性仍有几个问题有待阐明,但在遭遇缺血/再灌注损伤的临床环境中,H2S水平的升高可能具有治疗潜力。这篇综述文章概述了目前对这种令人兴奋的分子在心肌缺血/再灌注情况下作用的理解。