Department of Physiology, Semmelweis University, 1088 Budapest, Hungary.
Department of Neurology, Semmelweis University, 1088 Budapest, Hungary.
Biomolecules. 2020 Dec 16;10(12):1685. doi: 10.3390/biom10121685.
A better understanding of the regulation of cerebrovascular circulation is of great importance because stroke and other cerebrovascular diseases represent a major concern in healthcare leading to millions of deaths yearly. The circulation of the central nervous system is regulated in a highly complex manner involving many local factors and hydrogen sulfide (HS) is emerging as one such possible factor. Several lines of evidence support that HS takes part in the regulation of vascular tone. Examinations using either exogenous treatment with HS donor molecules or alterations to the enzymes that are endogenously producing this molecule revealed numerous important findings about its physiological and pathophysiological role. The great majority of these studies were performed on vessel segments derived from the systemic circulation but there are important observations made using cerebral vessels as well. The findings of these experimental works indicate that HS is having a complex, pleiotropic effect on the vascular wall not only in the systemic circulation but in the cerebrovascular region as well. In this review, we summarize the most important experimental findings related to the potential role of HS in the cerebral circulation.
更好地了解脑血管循环的调节非常重要，因为中风和其他脑血管疾病是医疗保健中的一个主要关注点，每年导致数百万人死亡。中枢神经系统的循环以高度复杂的方式调节，涉及许多局部因素，而硫化氢（HS）就是这样一种可能的因素。有几条证据表明 HS 参与了血管张力的调节。使用 HS 供体分子的外源性处理或改变内源性产生这种分子的酶的方法进行的检查揭示了关于其生理和病理生理作用的许多重要发现。这些研究中的绝大多数是在源自体循环的血管段上进行的，但也有使用脑血管进行的重要观察。这些实验工作的结果表明，HS 对血管壁具有复杂的、多效性的影响，不仅在体循环中，而且在脑血管区域也是如此。在这篇综述中，我们总结了与 HS 在脑血管循环中潜在作用相关的最重要的实验发现。
