维生素 B12 和叶酸对同型半胱氨酸水平的抑制：杰克逊心脏研究中的年龄和性别依赖性。
Suppression of homocysteine levels by vitamin B12 and folates: age and gender dependency in the Jackson Heart Study.
机构信息
Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, USA.
出版信息
Am J Med Sci. 2012 Aug;344(2):110-5. doi: 10.1097/MAJ.0b013e31823782a5.
INTRODUCTION
To examine factors potentially contributing to premature cardiovascular disease mortality in African Americans (40% versus 20% all other populations), plasma homocysteine, serum vitamin B12 and folate levels were examined for African American participants in the Jackson Heart Study.
METHODS
Of 5192 African American Jackson Heart Study participants (21-94 years), 5064 (mean age, 55 ± 13 years; 63% female) had homocysteine levels measured via fasting blood samples, with further assessments of participants' vitamin B12 (n = 1790) and folate (n = 1788) levels. Regression analyses were used to examine age, gender, vitamin B12 and folate with homocysteine levels.
RESULTS
Homocysteine levels, a purported surrogate risk factor for cardiovascular disease, increased with age, were inversely proportional to folate and vitamin B12 levels (P < 0.001) and were higher for men of all ages.
CONCLUSIONS
The results show that, as with other populations, age, gender, vitamin B12 and folate may predict homocysteine levels for African Americans. Diet may be an important predictive factor as well, given the relationships that were observed between plasma homocysteine and serum B vitamin levels.
简介
为了研究导致非裔美国人（40%比其他所有人群的 20%）过早死于心血管疾病的潜在因素，研究人员检查了参与杰克逊心脏研究的非裔美国人的血浆同型半胱氨酸、血清维生素 B12 和叶酸水平。
方法
在 5192 名非裔美国杰克逊心脏研究参与者（21-94 岁）中，有 5064 名（平均年龄 55 ± 13 岁；63%为女性）通过空腹血液样本测量了同型半胱氨酸水平，并进一步评估了参与者的维生素 B12（n = 1790）和叶酸（n = 1788）水平。回归分析用于检查年龄、性别、维生素 B12 和叶酸与同型半胱氨酸水平的关系。
结果
同型半胱氨酸水平是心血管疾病的一个潜在替代风险因素，随着年龄的增长而增加，与叶酸和维生素 B12 水平呈反比（P < 0.001），并且在所有年龄段的男性中都较高。
结论
结果表明，与其他人群一样，年龄、性别、维生素 B12 和叶酸可能预测非裔美国人的同型半胱氨酸水平。鉴于观察到的血浆同型半胱氨酸与血清 B 族维生素水平之间的关系，饮食可能也是一个重要的预测因素。
Zotero 插件