Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Sci China Life Sci. 2011 Nov;54(11):988-98. doi: 10.1007/s11427-011-4247-x. Epub 2011 Dec 16.
Functional proteomics can be defined as a strategy to couple proteomic information with biochemical and physiological analyses with the aim of understanding better the functions of proteins in normal and diseased organs. In recent years, a variety of publicly available bioinformatics databases have been developed to support protein-related information management and biological knowledge discovery. In addition to being used to annotate the proteome, these resources also offer the opportunity to develop global approaches to the study of the functional role of proteins both in health and disease. Here, we present a comprehensive review of the major human protein bioinformatics databases. We conclude this review by discussing a few examples that illustrate the importance of these databases in functional proteomics research.
功能蛋白质组学可以被定义为一种策略，将蛋白质组学信息与生化和生理学分析相结合，旨在更好地理解蛋白质在正常和患病器官中的功能。近年来，开发了各种公开可用的生物信息学数据库，以支持蛋白质相关信息管理和生物知识发现。除了用于注释蛋白质组外，这些资源还为在健康和疾病中研究蛋白质的功能作用提供了全局方法的机会。在这里，我们对主要的人类蛋白质生物信息学数据库进行了全面的综述。我们通过讨论一些例子来结束本文，这些例子说明了这些数据库在功能蛋白质组学研究中的重要性。
