酿酒酵母细胞壁生物发生的调控：细胞壁完整性信号通路。
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
机构信息
Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA.
出版信息
Genetics. 2011 Dec;189(4):1145-75. doi: 10.1534/genetics.111.128264.
Abstract
The yeast cell wall is a strong, but elastic, structure that is essential not only for the maintenance of cell shape and integrity, but also for progression through the cell cycle. During growth and morphogenesis, and in response to environmental challenges, the cell wall is remodeled in a highly regulated and polarized manner, a process that is principally under the control of the cell wall integrity (CWI) signaling pathway. This pathway transmits wall stress signals from the cell surface to the Rho1 GTPase, which mobilizes a physiologic response through a variety of effectors. Activation of CWI signaling regulates the production of various carbohydrate polymers of the cell wall, as well as their polarized delivery to the site of cell wall remodeling. This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress. The interface of this signaling pathway with other pathways that contribute to the maintenance of cell wall integrity is also discussed.
摘要
酵母细胞壁是一种坚固而有弹性的结构，不仅对于维持细胞形状和完整性至关重要，而且对于细胞周期的进展也至关重要。在生长和形态发生过程中，以及对环境挑战的反应中，细胞壁以高度调控和极化的方式进行重塑，这个过程主要受到细胞壁完整性（CWI）信号通路的控制。该通路将细胞壁表面的壁压信号传递给 Rho1 GTPase，后者通过多种效应物调动生理反应。CWI 信号的激活调节细胞壁中各种碳水化合物聚合物的产生，以及它们向细胞壁重塑部位的极化输送。本文综述了酿酒酵母通过细胞周期和响应细胞壁压力的 CWI 信号，同时还讨论了该信号通路与其他有助于维持细胞壁完整性的通路的相互作用。
相似文献
1
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.酿酒酵母细胞壁生物发生的调控：细胞壁完整性信号通路。
Genetics. 2011 Dec;189(4):1145-75. doi: 10.1534/genetics.111.128264.
2
Coordination of the Cell Wall Integrity and High-Osmolarity Glycerol Pathways in Response to Ethanol Stress in Saccharomyces cerevisiae.在酿酒酵母中响应乙醇胁迫时，细胞壁完整性和高渗透压甘油途径的协调。
Appl Environ Microbiol. 2019 Jul 18;85(15). doi: 10.1128/AEM.00551-19. Print 2019 Aug 1.
3
Cell wall integrity signaling in Saccharomyces cerevisiae.酿酒酵母中的细胞壁完整性信号传导
Microbiol Mol Biol Rev. 2005 Jun;69(2):262-91. doi: 10.1128/MMBR.69.2.262-291.2005.
4
Rewiring the yeast cell wall integrity (CWI) pathway through a synthetic positive feedback circuit unveils a novel role for the MAPKKK Ssk2 in CWI pathway activation.通过合成正反馈回路重塑酵母细胞壁完整性 (CWI) 途径，揭示了 MAPKKK Ssk2 在 CWI 途径激活中的新作用。
FEBS J. 2020 Nov;287(22):4881-4901. doi: 10.1111/febs.15288. Epub 2020 Mar 30.
5
Shedding light on autophagy coordinating with cell wall integrity signaling to govern pathogenicity of .阐明自噬与细胞壁完整性信号协调作用以控制 的致病性。
Autophagy. 2020 May;16(5):900-916. doi: 10.1080/15548627.2019.1644075. Epub 2019 Jul 24.
6
Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase.Zds1/Zds2-PP2ACdc55复合物决定了Rho1 GTP酶的信号输出。
J Cell Biol. 2016 Jan 4;212(1):51-61. doi: 10.1083/jcb.201508119.
7
How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity.我该如何开始？感知细胞外压力以维持酵母细胞壁的完整性。
Eur J Cell Biol. 2011 Sep;90(9):740-4. doi: 10.1016/j.ejcb.2011.04.006. Epub 2011 Jun 2.
8
Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway.Mpt5p是酿酒酵母中一种促进应激耐受性和延长寿命的PUF蛋白，在细胞壁完整性途径上游发挥作用。
Eukaryot Cell. 2007 Feb;6(2):262-70. doi: 10.1128/EC.00188-06. Epub 2006 Dec 15.
9
Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae.细胞壁完整性途径的激活通过阻止酿酒酵母中 eisosome 的解体，负调控 TORC2-Ypk1/2 信号通路。
Commun Biol. 2024 Jun 11;7(1):722. doi: 10.1038/s42003-024-06411-2.
10
Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of .应激传感器Wsc1p和Mid2p的新型相互作用蛋白伙伴的鉴定及功能测试
G3 (Bethesda). 2019 Apr 9;9(4):1085-1102. doi: 10.1534/g3.118.200985.
引用本文的文献
1
Regulation of the cell wall integrity pathway at the contact site between mating partners in yeast.酵母中交配伴侣接触位点处细胞壁完整性途径的调控。
bioRxiv. 2025 Aug 13:2025.08.12.669915. doi: 10.1101/2025.08.12.669915.
2
3-Methyl pentanoic acid suppress gray mold disease potentially targeting cell-wall integrity (CWI) and mitogen-activated protein kinase (MAPK) pathways in Botrytis cinerea.3-甲基戊酸可能通过靶向灰葡萄孢中的细胞壁完整性（CWI）和丝裂原活化蛋白激酶（MAPK）途径来抑制灰霉病。
BMC Microbiol. 2025 Aug 1;25(1):470. doi: 10.1186/s12866-025-04180-4.
3
Glycerol bioconversion to biofuel and value-added products by yeasts.酵母将甘油生物转化为生物燃料和增值产品。
FEMS Yeast Res. 2025 Jan 30;25. doi: 10.1093/femsyr/foaf038.
4
Time-resolved transcriptomics of S. cerevisiae and S. pastorianus in response to plasma membrane stresses.酿酒酵母和巴斯德酵母响应质膜应激的时间分辨转录组学
Sci Data. 2025 Jul 16;12(1):1246. doi: 10.1038/s41597-025-05565-w.
5
α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.由GH13结构域酶介导的α-葡聚糖重塑塑造真菌细胞壁结构。
Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2505509122. doi: 10.1073/pnas.2505509122. Epub 2025 Jul 16.
6
Global changes in synthesis rates and mRNA stabilities during adaptive responses to cell wall stress in yeast.酵母对细胞壁应激的适应性反应过程中合成速率和mRNA稳定性的全局变化。
Sci Rep. 2025 Jul 12;15(1):25260. doi: 10.1038/s41598-025-08815-4.
7
CWI-MAPKs Regulate the Formation of Hyphopodia Required for Virulence in Ceratocystis fimbriata.CWI-MAPK调控帚状毛壳菌致病所需附着胞的形成。
Mol Plant Pathol. 2025 Jul;26(7):e70119. doi: 10.1111/mpp.70119.
8
The APSES transcription factor Swi6B upregulates transcription to enhance oxidative stress tolerance of .APSES转录因子Swi6B上调转录以增强……的氧化应激耐受性。
Appl Environ Microbiol. 2025 Jul 23;91(7):e0067925. doi: 10.1128/aem.00679-25. Epub 2025 Jun 18.
9
Silencing of and Shows the Importance of -Linked Glycosylation During the -Host Interaction.对[具体基因名称1]和[具体基因名称2]的沉默显示了在[病原体名称]-宿主相互作用过程中[糖基化类型]连接糖基化的重要性。
需注意，由于原文部分内容缺失具体信息，翻译后的内容也存在一定的不完整性，仅为根据格式要求给出的示例翻译。
J Fungi (Basel). 2025 May 2;11(5):352. doi: 10.3390/jof11050352.
10
Cell walls of filamentous fungi - challenges and opportunities for biotechnology.丝状真菌的细胞壁——生物技术面临的挑战与机遇
Appl Microbiol Biotechnol. 2025 May 24;109(1):125. doi: 10.1007/s00253-025-13512-3.
本文引用的文献
1
Mpk1 MAPK association with the Paf1 complex blocks Sen1-mediated premature transcription termination.Mpk1 MAPK 与 Paf1 复合物的关联阻止了 Sen1 介导的过早转录终止。
Cell. 2011 Mar 4;144(5):745-56. doi: 10.1016/j.cell.2011.01.034.
2
Rewiring of genetic networks in response to DNA damage.遗传网络对 DNA 损伤的响应重编。
Science. 2010 Dec 3;330(6009):1385-9. doi: 10.1126/science.1195618.
3
Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling.中断肌醇神经酰胺合成会触发 Stt4p 依赖性蛋白激酶 C 信号转导。
J Biol Chem. 2010 Dec 31;285(53):41947-60. doi: 10.1074/jbc.M110.188607. Epub 2010 Oct 23.
4
Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae.通过对酿酒酵母 wsc1 和 mid2 缺失菌株和嵌合传感器的转录谱分析，对传感器特异性应激反应进行表征。
OMICS. 2010 Dec;14(6):679-88. doi: 10.1089/omi.2010.0060. Epub 2010 Oct 20.
5
Together we are strong--cell wall integrity sensors in yeasts.众志成城——酵母细胞壁完整性传感器。
Yeast. 2010 Aug;27(8):531-40. doi: 10.1002/yea.1785.
6
Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.通过一种不涉及 Mpk1 和 SBF 的非催化机制激活细胞壁应激基因的转录报告基因。
Yeast. 2010 Aug;27(8):541-8. doi: 10.1002/yea.1782.
7
A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance.监控途径监测内质网的适应性，以控制其遗传。
Cell. 2010 Jul 23;142(2):256-69. doi: 10.1016/j.cell.2010.06.006. Epub 2010 Jul 8.
8
The cell wall integrity checkpoint: coordination between cell wall synthesis and the cell cycle.细胞壁完整性检查点：细胞壁合成与细胞周期的协调。
Yeast. 2010 Aug;27(8):513-9. doi: 10.1002/yea.1795.
9
Single-molecule atomic force microscopy reveals clustering of the yeast plasma-membrane sensor Wsc1.单分子原子力显微镜揭示了酵母质膜传感器 Wsc1 的聚集。
PLoS One. 2010 Jun 14;5(6):e11104. doi: 10.1371/journal.pone.0011104.
10
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.信息素诱导的酵母质膜磷脂酰肌醇-4,5-二磷酸分布各向异性是 MAPK 信号所必需的。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11805-10. doi: 10.1073/pnas.1005817107. Epub 2010 Jun 14.
Zotero 插件