阵发性夜间血红蛋白尿症伴左心室血栓形成，患者有胸腺瘤和再生障碍性贫血病史。

Paroxysmal nocturnal hemoglobinuria presenting with a left intraventricular thrombus in a patient with prior thymoma and aplastic anemia.

机构信息

Division of Hematology and Oncology, Memorial Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, United States of America.

出版信息

Clin Med Insights Oncol. 2011;5:343-8. doi: 10.4137/CMO.S8442. Epub 2011 Nov 3.

DOI:10.4137/CMO.S8442

PMID:22174595

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3236000/

Abstract

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed.

摘要

我们报告了一例 37 岁男性病例，他在因胸腺瘤相关再生障碍性贫血接受免疫抑制治疗两年后出现亚临床阵发性夜间血红蛋白尿（PNH），并发左心室心腔内血栓形成。本文还回顾了自身免疫与免疫抑制、再生障碍性贫血、胸腺瘤和 PNH 出现之间相互作用的相关文献。