Ruiz Patricia, Ray Meredith, Fisher Jeffrey, Mumtaz Moiz
Computational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA; E-Mail:
Int J Mol Sci. 2011;12(11):7469-80. doi: 10.3390/ijms12117469. Epub 2011 Oct 31.
Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use. The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models. This toolkit, when fully developed, will provide a platform that consists of a series of priority PBPK models of environmental pollutants. Presented here is work on recoded PBPK models for volatile organic compounds (VOCs) and metals. Good agreement was generally obtained between the original and the recoded models. This toolkit will be available for ATSDR scientists and public health assessors to perform simulations of exposures from contaminated environmental media at sites of concern and to help interpret biomonitoring data. It can be used as screening tools that can provide useful information for the protection of the public.
基于生理的药代动力学（PBPK）模型可用于确定体内剂量并加强暴露评估。目前有许多PBPK模型，但它们不易用于现场。有毒物质和疾病登记署（ATSDR）开展了转化研究，通过对已发表的PBPK模型进行重新编码来开发人类PBPK模型工具包。这个工具包完全开发完成后，将提供一个平台，该平台由一系列环境污染物的优先PBPK模型组成。本文介绍了对挥发性有机化合物（VOCs）和金属的重新编码PBPK模型的研究工作。原始模型和重新编码的模型之间总体上取得了良好的一致性。该工具包将可供ATSDR的科学家和公共卫生评估人员使用，以模拟来自受关注场所受污染环境介质的暴露情况，并帮助解释生物监测数据。它可以用作筛查工具，为保护公众提供有用信息。
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