Barnes D E, Robinson B, Csernansky J G, Bellows E P
Department of Veterans Affairs, Laboratory of Clinical Psychopharmacology, Palo Alto, CA 94304.
Pharmacol Biochem Behav. 1990 Aug;36(4):883-7. doi: 10.1016/0091-3057(90)90094-x.
The effects of dose, administration frequency, and behavioral testing conditions on the development of tolerance versus sensitization to haloperidol-induced catalepsy were tested in rats. Animals received daily or weekly injections of haloperidol (0.05-5.00 mg/kg SC) for up to 22 days. Catalepsy assessments were made either once or repeatedly using two tests: the horizontal bar and the inclined screen. Tolerance was found only in animals treated daily with haloperidol (1.5 mg/kg) and tested repeatedly on the horizontal bar. In contrast, sensitization was observed with various haloperidol doses, daily or weekly administration schedules (for most doses), either horizontal bar or inclined screen catalepsy tests, and repeated or single testing. Sensitization developed most strongly following weekly drug administration and repeated testing on the horizontal bar. No single experimental variable produced a definitive pattern of change in catalepsy over time. Dose, drug administration schedule, and behavioral test conditions all influenced the evolution of catalepsy during chronic haloperidol treatment.
在大鼠中测试了剂量、给药频率和行为测试条件对氟哌啶醇诱导的僵住症耐受性与敏化作用发展的影响。动物每天或每周接受氟哌啶醇（0.05 - 5.00 mg/kg皮下注射）注射，持续22天。使用横杆和倾斜屏幕两种测试方法，对僵住症进行单次或重复评估。仅在每天接受氟哌啶醇（1.5 mg/kg）治疗并在横杆上重复测试的动物中发现了耐受性。相比之下，在各种氟哌啶醇剂量、每日或每周给药方案（大多数剂量）、横杆或倾斜屏幕僵住症测试以及重复或单次测试中均观察到了敏化作用。在每周给药并在横杆上重复测试后，敏化作用最为强烈。没有单一的实验变量能产生随时间变化的僵住症明确变化模式。剂量、给药方案和行为测试条件均影响慢性氟哌啶醇治疗期间僵住症的演变。
