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智能决策支持系统有可能提高药物审查的质量和一致性。

The potential for intelligent decision support systems to improve the quality and consistency of medication reviews.

机构信息

School of Pharmacy, University of Tasmania, Tas., Australia.

出版信息

J Clin Pharm Ther. 2012 Aug;37(4):452-8. doi: 10.1111/j.1365-2710.2011.01327.x. Epub 2011 Dec 18.

Abstract

WHAT IS KNOWN AND OBJECTIVE

Drug-related problems (DRPs) are of serious concern worldwide, particularly for the elderly who often take many medications simultaneously. Medication reviews have been demonstrated to improve medication usage, leading to reductions in DRPs and potential savings in healthcare costs. However, medication reviews are not always of a consistently high standard, and there is often room for improvement in the quality of their findings. Our aim was to produce computerized intelligent decision support software that can improve the consistency and quality of medication review reports, by helping to ensure that DRPs relevant to a patient are overlooked less frequently. A system that largely achieved this goal was previously published, but refinements have been made. This paper examines the results of both the earlier and newer systems.

METHODS

Two prototype multiple-classification ripple-down rules medication review systems were built, the second being a refinement of the first. Each of the systems was trained incrementally using a human medication review expert. The resultant knowledge bases were analysed and compared, showing factors such as accuracy, time taken to train, and potential errors avoided.

RESULTS AND DISCUSSION

The two systems performed well, achieving accuracies of approximately 80% and 90%, after being trained on only a small number of cases (126 and 244 cases, respectively). Through analysis of the available data, it was estimated that without the system intervening, the expert training the first prototype would have missed approximately 36% of potentially relevant DRPs, and the second 43%. However, the system appeared to prevent the majority of these potential expert errors by correctly identifying the DRPs for them, leaving only an estimated 8% error rate for the first expert and 4% for the second.

WHAT IS NEW AND CONCLUSION

These intelligent decision support systems have shown a clear potential to substantially improve the quality and consistency of medication reviews, which should in turn translate into improved medication usage if they were implemented into routine use.

摘要

已知和目的

药物相关问题(DRPs)在全球范围内引起严重关注,尤其是对于经常同时服用多种药物的老年人。药物审查已被证明可以改善药物使用,从而减少 DRPs 并潜在节省医疗保健成本。然而,药物审查并不总是具有一致的高标准,并且在其发现的质量方面通常有改进的空间。我们的目标是开发计算机智能决策支持软件,通过帮助确保患者相关的 DRPs 不被经常忽略,从而提高药物审查报告的一致性和质量。以前发表了一个在很大程度上实现这一目标的系统,但已经进行了改进。本文研究了早期和较新系统的结果。

方法

构建了两个原型多分类波纹下降规则药物审查系统,第二个是第一个的改进。每个系统都使用人类药物审查专家进行增量训练。分析和比较了产生的知识库,显示了准确性、训练时间和避免的潜在错误等因素。

结果和讨论

两个系统表现良好,在仅接受少数病例(分别为 126 例和 244 例)培训后,准确率约为 80%和 90%。通过对可用数据的分析,估计如果没有系统干预,培训第一个原型的专家可能会错过大约 36%的潜在相关 DRPs,第二个则为 43%。然而,该系统似乎通过正确识别 DRPs 为专家提供了帮助,从而防止了大多数潜在的专家错误,第一个专家的估计错误率为 8%,第二个专家的错误率为 4%。

新内容和结论

这些智能决策支持系统显示出了显著提高药物审查质量和一致性的潜力,如果将其应用于常规使用中,应该会转化为改善药物使用。

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