Austin G E, Coulam C B, Ryan R J
Mayo Clin Proc. 1979 Jun;54(6):394-400.
We recently published evidence of the presence of circulating antibodies in the sera of patients who had the diagnosis of premature menopause syndrome. This led to the question: Is there a circulating antibody in the sera of patients with premature menopause syndrome which interferes with gonadotropin-luteinizing hormone (LH) receptor interaction on the luteal cell surface? Serum samples from 14 women with the diagnosis of Premature menopause syndrome were examined to see whether they would block the binding of 125I-labeled human chorionic gonadotropin (hCG) to human corpora lutea. All patients had spontaneous cessation of menses before the age of 35 years and documentation of increased gonadotropin secretion and failure of estrogen secretion. When the sera of the study group were incubated with 125I-labeled hCG and LH receptor from human corpora lutea, no difference in binding was observed when compared with controls. This suggests that there is no circulating antibody that interferes with hCG-LH receptor interaction and that would thereby lead to loss of ovarian function in premature menopause syndrome.
我们最近发表了关于诊断为早发性绝经综合征患者血清中存在循环抗体的证据。这引发了一个问题：早发性绝经综合征患者的血清中是否存在一种循环抗体，它会干扰黄体细胞表面促性腺激素 - 黄体生成素（LH）受体的相互作用？对14名诊断为早发性绝经综合征的女性血清样本进行检测，以观察它们是否会阻断125I标记的人绒毛膜促性腺激素（hCG）与人黄体的结合。所有患者均在35岁之前自然停经，并有促性腺激素分泌增加和雌激素分泌不足的记录。当研究组的血清与125I标记的hCG和人黄体的LH受体一起孵育时，与对照组相比，未观察到结合上的差异。这表明不存在干扰hCG - LH受体相互作用从而导致早发性绝经综合征患者卵巢功能丧失的循环抗体。
