Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Am J Clin Dermatol. 2012 Feb 1;13(1):29-36. doi: 10.2165/11593280-000000000-00000.
Recent data suggest a reduced risk of malignant melanoma (MM) among atopic dermatitis (AD) patients, but an increased risk of other skin cancers (including basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]).
We examined the association between AD and skin cancers in a large cohort study in Denmark from 1977 through 2006.
Our cohort consisted of 31 330 AD patients recorded in the Danish National Patient Registry, including AD patients admitted to hospitals and specialized outpatient clinics. Linkage to the Danish Cancer Registry allowed ascertainment of skin cancers. We calculated standardized incidence ratios (SIRs) and associated 95% confidence intervals (CIs) by comparing the incidence rate of skin cancers among AD patients with that among the general Danish population.
The overall observed number of MM cases among AD patients was 12, with 21 expected, yielding a SIR of 0.59 (95% CI 0.30, 1.02), with the most pronounced protective effect among AD patients with more than 5 years of follow-up (SIR = 0.46; 95% CI 0.19, 0.95). The corresponding SIRs for BCC and SCC were increased among AD patients (1.41 [95% CI 1.07, 1.83] and 2.48 [95% CI 1.00, 5.11], respectively).
Our findings support an inverse association between AD and MM, but an increased risk of BCC and SCC among AD patients.
最近的数据表明，特应性皮炎（AD）患者患恶性黑色素瘤（MM）的风险降低，但患其他皮肤癌（包括基底细胞癌[BCC]和鳞状细胞癌[SCC]）的风险增加。
我们在丹麦 1977 年至 2006 年的一项大型队列研究中研究了 AD 与皮肤癌之间的关联。
我们的队列包括 31330 名在丹麦国家患者登记处记录的 AD 患者，包括在医院和专门门诊就诊的 AD 患者。与丹麦癌症登记处的链接允许确定皮肤癌。我们通过比较 AD 患者与普通丹麦人群的皮肤癌发病率来计算标准化发病率比（SIR）和相关的 95%置信区间（CI）。
AD 患者中观察到的 MM 病例总数为 12 例，预期为 21 例，SIR 为 0.59（95%CI 0.30，1.02），在随访时间超过 5 年的 AD 患者中，保护作用最为明显（SIR=0.46；95%CI 0.19，0.95）。AD 患者的 BCC 和 SCC 的相应 SIR 升高（分别为 1.41[95%CI 1.07，1.83]和 2.48[95%CI 1.00，5.11]）。
我们的研究结果支持 AD 与 MM 之间存在负相关，但 AD 患者患 BCC 和 SCC 的风险增加。
