Medical Division, Maccabi Healthcare Services, Tel Aviv, Israel; Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel.
Br J Dermatol. 2015 Jan;172(1):202-7. doi: 10.1111/bjd.13213. Epub 2014 Nov 20.
The incidence of melanoma and keratinocyte cancers (KCs) is rising worldwide. Squamous cell carcinomas (SCCs) and basal cell carcinoma (BCCs) are the most common of all cancers.
To determine trends in the incidence of melanoma, BCC and SCC among 1·7 million members of Maccabi Healthcare Services (MHS) from 2006 to 2011.
Data on patients newly diagnosed with melanoma, SCC and BCC were collected from the MHS Cancer Registry and based on histology reports from the centralized pathology laboratory. Age-specific and overall age-adjusted European standardized rates were computed. Trends were estimated by calculating average annual percentage change (AAPC).
During the 6-year study period, 16,079 patients were diagnosed with at least one BCC, 4767 with SCC and 1264 with invasive melanoma. Age-standardized incidence rates were 188, 58 and 17 per 100,000 person years for BCC, SCC and melanoma, respectively. All lesions were more common among men and primarily affected the elderly. BCC rates were stable throughout the study period [AAPC -0·7%, 95% confidence interval (CI) -4·5 to 3·2], while the incidence of SCC increased significantly (AAPC 15·5%, 95% CI 2·6-30·0). In contrast, melanoma rates continuously decreased (AAPC -3·0%, 95%CI -4·5 to -0·1).
The incidence of KC in Israel is high. The disparities in incidence trends between SCC, BCC and melanoma allude to their different aetiologies. These findings underscore the importance of continuous monitoring, education and prevention programmes in a growing high-risk population.
黑色素瘤和角化细胞癌（KC）的发病率在全球范围内呈上升趋势。鳞状细胞癌（SCC）和基底细胞癌（BCC）是所有癌症中最常见的。
确定 2006 年至 2011 年间，Maccabi 医疗保健服务（MHS）的 170 万成员中黑色素瘤、BCC 和 SCC 的发病率趋势。
从 MHS 癌症登记处收集新诊断为黑色素瘤、SCC 和 BCC 的患者数据，并根据中央病理实验室的组织学报告。计算了特定年龄和总体年龄调整后的欧洲标准化率。通过计算平均年百分比变化（AAPC）来估计趋势。
在 6 年的研究期间，有 16079 名患者被诊断出患有至少一种 BCC，4767 名患有 SCC，1264 名患有侵袭性黑色素瘤。BCC、SCC 和黑色素瘤的年龄标准化发病率分别为每 100,000 人年 188、58 和 17 例。所有病变在男性中更为常见，主要影响老年人。整个研究期间，BCC 发病率保持稳定[AAPC-0.7%，95%置信区间（CI）-4.5 至 3.2]，而 SCC 的发病率显著增加[AAPC 15.5%，95%CI 2.6-30.0]。相比之下，黑色素瘤的发病率持续下降[AAPC-3.0%，95%CI-4.5 至-0.1]。
以色列的 KC 发病率很高。SCC、BCC 和黑色素瘤之间发病率趋势的差异暗示了它们不同的病因。这些发现强调了在不断增长的高危人群中持续监测、教育和预防计划的重要性。
