肺内脂多糖暴露可上调新生儿脑干细胞因子的表达。
Intrapulmonary lipopolysaccharide exposure upregulates cytokine expression in the neonatal brainstem.
机构信息
Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106-6010, USA.
出版信息
Acta Paediatr. 2012 May;101(5):466-71. doi: 10.1111/j.1651-2227.2011.02564.x. Epub 2012 Jan 11.
Abstract
UNLABELLED
Perinatal inflammation and neonatal sepsis trigger lung and brain injury. We hypothesized that endotoxin exposure in the immature lung upregulates proinflammatory cytokine expression in the brainstem and impairs respiratory control. Lipopolysaccharide (LPS) or saline was administered intratracheally to vagal intact or denervated rat pups. LPS increased brainstem IL-1β and vagotomy blunted this response. There was an attenuated ventilatory response to hypoxia and increased brainstem IL-1β expression after LPS.
CONCLUSION
Intratracheal endotoxin exposure in rat pups is associated with upregulation of IL-1β in the brainstem that is vagally mediated and associated with an impaired hypoxic ventilatory response.
摘要
未加标签
围产期炎症和新生儿败血症会引发肺部和脑部损伤。我们假设，不成熟肺部的内毒素暴露会在上脑干上调促炎细胞因子的表达，并损害呼吸控制。将脂多糖（LPS）或生理盐水通过气管内滴注到迷走神经完整或去神经的大鼠幼仔中。LPS 增加了脑干中的 IL-1β，而迷走神经切断术则减弱了这种反应。LPS 后，对缺氧的通气反应减弱，并且脑干中的 IL-1β表达增加。
结论
在大鼠幼仔中经气管内内毒素暴露与脑干中 IL-1β的上调有关，该上调是通过迷走神经介导的，并与缺氧通气反应受损有关。
相似文献
1
Intrapulmonary lipopolysaccharide exposure upregulates cytokine expression in the neonatal brainstem.
Acta Paediatr. 2012 May;101(5):466-71. doi: 10.1111/j.1651-2227.2011.02564.x. Epub 2012 Jan 11.
2
Vagal afferents modulate cytokine-mediated respiratory control at the neonatal medulla oblongata.
Respir Physiol Neurobiol. 2011 Sep 30;178(3):458-64. doi: 10.1016/j.resp.2011.03.003. Epub 2011 Mar 17.
3
Lung inflammation induces IL-1β expression in hypoglossal neurons in rat brainstem.
Respir Physiol Neurobiol. 2013 Aug 1;188(1):21-8. doi: 10.1016/j.resp.2013.04.022. Epub 2013 May 3.
4
Intratracheal LPS administration attenuates the acute hypoxic ventilatory response: Role of brainstem IL-1β receptors.
Respir Physiol Neurobiol. 2017 Aug;242:45-51. doi: 10.1016/j.resp.2017.03.005. Epub 2017 Mar 19.
5
Vagal nerve stimulation attenuates IL-6 and TNFα expression in respiratory regions of the developing rat brainstem.
Respir Physiol Neurobiol. 2016 Jul 15;229:1-4. doi: 10.1016/j.resp.2016.03.014. Epub 2016 Apr 2.
6
Effect of endotoxin and interleukin-1beta on corticotropin-releasing-factor and prostaglandin release by rat brainstem slices.
J Neuroendocrinol. 1998 Jun;10(6):429-36. doi: 10.1046/j.1365-2826.1998.00222.x.
7
A critical postnatal period of heightened vulnerability to lipopolysaccharide.
Respir Physiol Neurobiol. 2016 Oct;232:26-34. doi: 10.1016/j.resp.2016.06.003. Epub 2016 Jun 18.
8
Airway inflammation and central respiratory control: results from in vivo and in vitro neonatal rat.
Respir Physiol Neurobiol. 2011 Sep 30;178(3):414-21. doi: 10.1016/j.resp.2011.05.008. Epub 2011 May 14.
9
Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain.
Neonatology. 2007;92(4):269-78. doi: 10.1159/000105493. Epub 2007 Jul 11.
10
Brainstem inflammation modulates the ventilatory pattern and its variability after acute lung injury in rodents.
J Physiol. 2020 Jul;598(13):2791-2811. doi: 10.1113/JP279177. Epub 2020 May 21.
引用本文的文献
1
Ibuprofen Does Not Prevent Inhibition of Fetal Breathing Movements Caused by Intrauterine Inflammation in Fetal Sheep.
Int J Mol Sci. 2025 Jun 11;26(12):5591. doi: 10.3390/ijms26125591.
2
AMPK Phosphorylates LMX1b to Regulate a Brainstem Neurogenic Network Important for Control of Breathing in Neonatal Mice.
Int J Mol Sci. 2024 Dec 30;26(1):213. doi: 10.3390/ijms26010213.
3
Mechanical ventilation induces brainstem inflammation in preterm fetal sheep.
Front Pediatr. 2023 Oct 23;11:1225294. doi: 10.3389/fped.2023.1225294. eCollection 2023.
4
Chorioamnionitis, Inflammation and Neonatal Apnea: Effects on Preterm Neonatal Brainstem and on Peripheral Airways: Chorioamnionitis and Neonatal Respiratory Functions.
Children (Basel). 2021 Oct 15;8(10):917. doi: 10.3390/children8100917.
5
Perinatal Hypoxemia and Oxygen Sensing.
Compr Physiol. 2021 Apr 1;11(2):1653-1677. doi: 10.1002/cphy.c190046.
6
Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity.
Respir Physiol Neurobiol. 2020 Mar;274:103357. doi: 10.1016/j.resp.2019.103357. Epub 2019 Dec 30.
7
Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront.
Pediatr Res. 2020 Jan;87(2):210-220. doi: 10.1038/s41390-019-0527-0. Epub 2019 Aug 4.
8
Rodent models of respiratory control and respiratory system development-Clinical significance.
Respir Physiol Neurobiol. 2019 Oct;268:103249. doi: 10.1016/j.resp.2019.06.006. Epub 2019 Jul 14.
9
Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.
J Physiol. 2018 Aug;596(15):3043-3065. doi: 10.1113/JP275890. Epub 2018 Jun 28.
10
The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins.
Front Cell Neurosci. 2018 Feb 1;12:26. doi: 10.3389/fncel.2018.00026. eCollection 2018.
本文引用的文献
1
Intermittent hypoxic episodes in preterm infants: do they matter?
Neonatology. 2011;100(3):303-10. doi: 10.1159/000329922. Epub 2011 Oct 3.
2
Airway inflammation and central respiratory control: results from in vivo and in vitro neonatal rat.
Respir Physiol Neurobiol. 2011 Sep 30;178(3):414-21. doi: 10.1016/j.resp.2011.05.008. Epub 2011 May 14.
3
Vagal afferents modulate cytokine-mediated respiratory control at the neonatal medulla oblongata.
Respir Physiol Neurobiol. 2011 Sep 30;178(3):458-64. doi: 10.1016/j.resp.2011.03.003. Epub 2011 Mar 17.
4
Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?
Neonatology. 2011;99(3):177-87. doi: 10.1159/000320170. Epub 2010 Sep 28.
5
Inflammatory response to oxygen and endotoxin in newborn rat lung ventilated with low tidal volume.
Pediatr Res. 2010 Jul;68(1):63-9. doi: 10.1203/PDR.0b013e3181e17caa.
6
Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure.
J Appl Physiol (1985). 2010 May;108(5):1347-56. doi: 10.1152/japplphysiol.01392.2009. Epub 2010 Mar 11.
7
Bronchopulmonary dysplasia in a rat model induced by intra-amniotic inflammation and postnatal hyperoxia: morphometric aspects.
Pediatr Res. 2009 Mar;65(3):323-7. doi: 10.1203/PDR.0b013e318193f165.
8
Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilation.
Pediatr Res. 2009 Jan;65(1):67-71. doi: 10.1203/PDR.0b013e318189487e.
9
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate.
Arch Dis Child Fetal Neonatal Ed. 2008 Nov;93(6):F455-61. doi: 10.1136/adc.2007.121327. Epub 2008 Aug 1.
10
Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants.
J Pediatr. 2008 Aug;153(2):160-3. doi: 10.1016/j.jpeds.2008.04.057.
Zotero 插件