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2
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Am J Pathol. 2019 May;189(5):999-1014. doi: 10.1016/j.ajpath.2019.01.014. Epub 2019 Feb 19.
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Pre-Vent: the prematurity-related ventilatory control study.Pre-Vent：与早产相关的通气控制研究。
Pediatr Res. 2019 May;85(6):769-776. doi: 10.1038/s41390-019-0317-8. Epub 2019 Feb 1.
4
Initial Oxygen Use for Preterm Newborn Resuscitation: A Systematic Review With Meta-analysis.初始氧疗用于早产儿复苏：系统评价与荟萃分析。
Pediatrics. 2019 Jan;143(1). doi: 10.1542/peds.2018-1828.
5
Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.新生儿间歇性低氧血症事件与 36 孕周后支气管肺发育不良的诊断相关。
Pediatr Res. 2019 Feb;85(3):318-323. doi: 10.1038/s41390-018-0253-z. Epub 2018 Dec 12.
6
Combined effects of intermittent hyperoxia and intermittent hypercapnic hypoxia on respiratory control in neonatal rats.间歇性高氧和间歇性高碳酸血症性缺氧对新生大鼠呼吸控制的联合作用
Respir Physiol Neurobiol. 2019 Feb;260:70-81. doi: 10.1016/j.resp.2018.11.002. Epub 2018 Nov 12.
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Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia.新生儿早期的氧饱和度降低可预测支气管肺发育不良的发生。
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8
Early inspired oxygen and intermittent hypoxemic events in extremely premature infants are associated with asthma medication use at 2 years of age.极早产儿早期吸氧和间歇性低氧事件与 2 岁时使用哮喘药物有关。
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呼吸控制与呼吸系统发育的啮齿动物模型——临床意义

Rodent models of respiratory control and respiratory system development-Clinical significance.

作者信息

Dylag Andrew M, Raffay Thomas M

机构信息

Division of Neonatology, Golisano Children's Hospital, Department of Pediatrics, University of Rochester, Rochester, NY, United States.

Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.

出版信息

Respir Physiol Neurobiol. 2019 Oct;268:103249. doi: 10.1016/j.resp.2019.06.006. Epub 2019 Jul 14.

DOI:10.1016/j.resp.2019.06.006
PMID:31315068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6692228/
Abstract

The newborn infant's respiratory system must rapidly adapt to extra-uterine life. Neonatal rat and mouse models have been used to investigate early development of respiratory control and reactivity in both health and disease. This review highlights several rodent models of control of breathing and respiratory system development (including pulmonary function), discusses their translational strengths and limitations, and underscores the importance of creating clinically relevant models applicable to the human infant.

摘要

新生婴儿的呼吸系统必须迅速适应宫外生活。新生大鼠和小鼠模型已被用于研究健康和疾病状态下呼吸控制及反应性的早期发育。本综述重点介绍了几种呼吸控制和呼吸系统发育（包括肺功能）的啮齿动物模型，讨论了它们在转化研究中的优势和局限性，并强调了创建适用于人类婴儿的临床相关模型的重要性。