呼吸控制与呼吸系统发育的啮齿动物模型——临床意义
Rodent models of respiratory control and respiratory system development-Clinical significance.
作者信息
Dylag Andrew M, Raffay Thomas M
机构信息
Division of Neonatology, Golisano Children's Hospital, Department of Pediatrics, University of Rochester, Rochester, NY, United States.
Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.
出版信息
Respir Physiol Neurobiol. 2019 Oct;268:103249. doi: 10.1016/j.resp.2019.06.006. Epub 2019 Jul 14.
Abstract
The newborn infant's respiratory system must rapidly adapt to extra-uterine life. Neonatal rat and mouse models have been used to investigate early development of respiratory control and reactivity in both health and disease. This review highlights several rodent models of control of breathing and respiratory system development (including pulmonary function), discusses their translational strengths and limitations, and underscores the importance of creating clinically relevant models applicable to the human infant.
摘要
新生婴儿的呼吸系统必须迅速适应宫外生活。新生大鼠和小鼠模型已被用于研究健康和疾病状态下呼吸控制及反应性的早期发育。本综述重点介绍了几种呼吸控制和呼吸系统发育（包括肺功能）的啮齿动物模型，讨论了它们在转化研究中的优势和局限性，并强调了创建适用于人类婴儿的临床相关模型的重要性。
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