Mehić B, Konjicija A, Zutić H, Lukić Z
Klinika za plućne bolesti Sarajevo.
Plucne Bolesti. 1990 Jan-Jun;42(1-2):104-6.
Fifteen asthmatic patients were prospectively selected. If they had more than 450 eosinophils in peripheral blood on admission to hospital treatment and if before BAL had been performed they were not treated by corticosteroids. No associated disease was found which could cause the increased number of eosinophils in peripheral blood except bronchial asthma. BAL was performed when the subjects tested had no dyspnea, usually 1-3 days after the hospital admission. In contrast to blood eosinophilia, increase of eosinophils number in BAL was found to correlate to impairment of clinically measured parameters such as: ventilation level of blood gases and duration of hospitalisation. On the contrary there was no correlation between the level of blood eosinophilia and gas disturbance and duration of hospitalisation. Eosinophilic proteins (MBP, ECP, EPX, EPO) are not the only that harmfully effect the lung cells in the asthmatic attack but the fact that their level in lavage fluid correlates to eosinophilia degree in BAL is evident so the correlation between the number of eosinophils in BAL and impairment of clinically measured parameters is clear.
前瞻性选取了15例哮喘患者。入选标准为入院接受治疗时外周血嗜酸性粒细胞计数超过450，且在进行支气管肺泡灌洗（BAL）之前未接受过皮质类固醇治疗。除支气管哮喘外，未发现其他可导致外周血嗜酸性粒细胞增多的相关疾病。当受试者无呼吸困难时进行BAL，通常在入院后1 - 3天进行。与血液嗜酸性粒细胞增多症相反，发现BAL中嗜酸性粒细胞数量的增加与临床测量参数的损害相关，如：血液气体的通气水平和住院时间。相反，血液嗜酸性粒细胞水平与气体紊乱及住院时间之间无相关性。嗜酸性粒细胞蛋白（MBP、ECP、EPX、EPO）并非哮喘发作时唯一对肺细胞产生有害影响的物质，但灌洗液中它们的水平与BAL中嗜酸性粒细胞增多程度相关这一事实是明显的，因此BAL中嗜酸性粒细胞数量与临床测量参数损害之间的相关性是明确的。
