Azofra J, Sastre J, Gómez B, Rivas F, Sastre A
Allergol Immunopathol (Madr). 1986 Jul-Aug;14(4):295-301.
We report the correlation between blood eosinophilia obtained by chamber count, percent in peripheral blood and the resulting value of this percent by the total number of leukocytes, together with the nasal and sputum eosinophilia and basophils in blood, in 57 asthmatic patients. Seventeen of them were on treatment with systemic steroids. We found blood eosinophilia in 24 patients (42%), being the chamber count method the most reliable. There was a significant difference in blood eosinophils between symptomatic and asymptomatic patients (p less than 0.05) without systemic steroid treatment. We did not find correlation between eosinophilia and the type of asthma (intrinsic-extrinsic). Only 5 out of 40 patients had eosinophilia on nasal smear, all with rhinitic symptoms. We studied sputum eosinophils in 40 out of 57 patients. Thirty (75%) had eosinophilia while only 45% of them had blood eosinophilia. Neither did we find correlation between blood and sputum eosinophilia (p greater than 0.05). We also encountered basophilia in 11 patients (19.2%). The number of basophils was inferior in asymptomatic patients treated with systemic steroids than in asymptomatic without systemic steroid treatment. Any relation between number of basophils, kind of asthma or clinical status was not observed. We did not find correlation between number of basophils and eosinophils in blood (r = 0.24; p greater than 0.05).
我们报告了57例哮喘患者通过计数板计数获得的血液嗜酸性粒细胞、外周血百分比及其与白细胞总数得出的该百分比值之间的相关性，以及鼻和痰液嗜酸性粒细胞及血液中的嗜碱性粒细胞情况。其中17例患者正在接受全身用类固醇治疗。我们发现24例患者（42%）存在血液嗜酸性粒细胞增多，计数板计数法最为可靠。在未接受全身用类固醇治疗的有症状和无症状患者之间，血液嗜酸性粒细胞存在显著差异（p小于0.05）。我们未发现嗜酸性粒细胞增多与哮喘类型（内源性-外源性）之间存在相关性。40例患者中只有5例鼻涂片显示嗜酸性粒细胞增多，均有鼻炎症状。我们对57例患者中的40例进行了痰液嗜酸性粒细胞研究。30例（75%）有嗜酸性粒细胞增多，而其中只有45%有血液嗜酸性粒细胞增多。我们也未发现血液和痰液嗜酸性粒细胞增多之间存在相关性（p大于0.05）。我们还在11例患者（19.2%）中发现了嗜碱性粒细胞增多。接受全身用类固醇治疗的无症状患者中的嗜碱性粒细胞数量低于未接受全身用类固醇治疗的无症状患者。未观察到嗜碱性粒细胞数量、哮喘类型或临床状态之间的任何关系。我们未发现血液中嗜碱性粒细胞数量与嗜酸性粒细胞数量之间存在相关性（r = 0.24；p大于0.05）。
